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• W1987702980 abstract "Preterm premature rupture of membranes (PPROM) is responsible for one third of all preterm births (PTBs). We have recently demonstrated that long noncoding RNAs (lncRNAs) are differentially expressed in human placentas derived from PPROM, PTB, premature rupture of the membranes (PROM), and full-term birth (FTB), and determined the major biological pathways involved in PPROM.Here, we further investigated the relationship of lncRNAs, which are differentially expressed in spontaneous PTB (sPTB) and PPROM placentas and are found to overlap a coding locus, with the differential expression of transcribed mRNAs at the same locus. Ten lncRNAs (five up-regulated and five down-regulated) and the lncRNA-associated 10 mRNAs (six up- and four down-regulated), which were identified by microarray in comparing PPROM vs. sPTB, were then validated by real-time quantitative PCR.A total of 62 (38 up- and 24 down-regulated) and 1,923 (790 up- and 1,133 down-regulated) lncRNAs were identified from placentas of premature labor (sPTB + PPROM), as compared to those from full-term labor (FTB + PROM) and from premature rupture of membranes (PPROM + PROM), as compared to those from non-rupture of membranes (sPTB + FTB), respectively. We found that a correlation existed between differentially expressed lncRNAs and their associated mRNAs, which could be grouped into four categories based on the gene strand (sense or antisense) of lncRNA and its paired transcript. These findings suggest that lncRNA regulates mRNA transcription through differential mechanisms. Differential expression of the transcripts PPP2R5C, STAM, TACC2, EML4, PAM, PDE4B, STAM, PPP2R5C, PDE4B, and EGFR indicated a co-expression among these mRNAs, which are involved in the ubiquitine-proteasome system (UPS), in addition to signaling transduction and beta adrenergic signaling, suggesting that imbalanced regulation of UPS may present an additional mechanism underlying the premature rupture of membrane in PPROM.Differentially expressed lncRNAs that were identified from the human placentas of sPTB and PPROM may regulate their associated mRNAs through differential mechanisms and connect the ubiquitin-proteasome system with infection-inflammation pathways. Although the detailed mechanisms by which lncRNAs regulate their associated mRNAs in sPTB and PPROM are yet to be clarified, our findings open a new approach to explore the pathogenesis of sPTB and PPROM." @default.
• W1987702980 created "2016-06-24" @default.
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• W1987702980 date "2015-02-15" @default.
• W1987702980 modified "2023-10-05" @default.
• W1987702980 title "Epigenetic regulation of lncRNA connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes" @default.
• W1987702980 cites W1886309510 @default.
• W1987702980 cites W1963967499 @default.
• W1987702980 cites W1969715471 @default.
• W1987702980 cites W1979662111 @default.
• W1987702980 cites W1985213868 @default.
• W1987702980 cites W1986775143 @default.
• W1987702980 cites W1992114227 @default.
• W1987702980 cites W1992389076 @default.
• W1987702980 cites W1992741792 @default.
• W1987702980 cites W1995852498 @default.
• W1987702980 cites W1998360818 @default.
• W1987702980 cites W1999307118 @default.
• W1987702980 cites W1999677921 @default.
• W1987702980 cites W2000137894 @default.
• W1987702980 cites W2001730700 @default.
• W1987702980 cites W2006556963 @default.
• W1987702980 cites W2007326882 @default.
• W1987702980 cites W2010691380 @default.
• W1987702980 cites W2011598785 @default.
• W1987702980 cites W2011629791 @default.
• W1987702980 cites W2014881329 @default.
• W1987702980 cites W2016211915 @default.
• W1987702980 cites W2021900499 @default.
• W1987702980 cites W2025388673 @default.
• W1987702980 cites W2026913745 @default.
• W1987702980 cites W2029320528 @default.
• W1987702980 cites W2030047242 @default.
• W1987702980 cites W2030246164 @default.
• W1987702980 cites W2035031476 @default.
• W1987702980 cites W2036145275 @default.
• W1987702980 cites W2038793226 @default.
• W1987702980 cites W2039816251 @default.
• W1987702980 cites W2043457433 @default.
• W1987702980 cites W2051278182 @default.
• W1987702980 cites W2051566370 @default.
• W1987702980 cites W2051868855 @default.
• W1987702980 cites W2052741109 @default.
• W1987702980 cites W2055929468 @default.
• W1987702980 cites W2056106885 @default.
• W1987702980 cites W2057481290 @default.
• W1987702980 cites W2058056541 @default.
• W1987702980 cites W2058451329 @default.
• W1987702980 cites W2058970225 @default.
• W1987702980 cites W2059968749 @default.
• W1987702980 cites W2060515857 @default.
• W1987702980 cites W2062147610 @default.
• W1987702980 cites W2063521597 @default.
• W1987702980 cites W2064849799 @default.
• W1987702980 cites W2067746378 @default.
• W1987702980 cites W2067765119 @default.
• W1987702980 cites W2070777085 @default.
• W1987702980 cites W2074033424 @default.
• W1987702980 cites W2085364628 @default.
• W1987702980 cites W2089043517 @default.
• W1987702980 cites W2092188551 @default.
• W1987702980 cites W2097948046 @default.
• W1987702980 cites W2098103685 @default.
• W1987702980 cites W2098979982 @default.
• W1987702980 cites W2102462903 @default.
• W1987702980 cites W2110356447 @default.
• W1987702980 cites W2111688179 @default.
• W1987702980 cites W2116443392 @default.
• W1987702980 cites W2117391818 @default.
• W1987702980 cites W2121352589 @default.
• W1987702980 cites W2125093810 @default.
• W1987702980 cites W2128086758 @default.
• W1987702980 cites W2128619556 @default.
• W1987702980 cites W2129375421 @default.
• W1987702980 cites W2130313087 @default.
• W1987702980 cites W2130388134 @default.
• W1987702980 cites W2133911610 @default.
• W1987702980 cites W2134368004 @default.
• W1987702980 cites W2134931712 @default.
• W1987702980 cites W2135019671 @default.
• W1987702980 cites W2135314242 @default.
• W1987702980 cites W2135725493 @default.
• W1987702980 cites W2138657304 @default.
• W1987702980 cites W2141337702 @default.

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