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• W1987707941 abstract "The presence of α-defensins in bronchoalveolar lavage fluid (BALF) was investigated in a cohort of preterm newborns with gestational age (GA) ≤30 wk. Specimens were collected during the first week of life from 24 preterm neonates mechanically ventilated. The studied population was divided into two groups: pneumonia group of nine neonates suffering from pulmonary infection (GA: 26.1 ± 2.1 wk; birth weight: 787.4 ± 309.9 g), with or without associated bloodstream infection, and nonpneumonia group of 15 neonates (GA: 27.7 ± 2.0 wk; birth weight: 1019.0 ± 319.8 g). BALF culture was positive for CONS (n = 5), Staphylococcus aureus (n = 1), and Candida spp (n = 3). BALF samples were analyzed by HPLC-electrospray Ionization-mass spectrometer. The α-defensins 1–4 concentration, absolute and differential white cells count were measured. Relative amounts of α-defensins 1–4 and the absolute number of neutrophils were found significantly higher in the pneumonia group with respect to the nonpneumonia group (p < 0.05). Moreover, positive significant correlations between the number of neutrophils and the α-defensins 1–3 levels were observed. In conclusion, our data show that preterm newborns, also at the lower GA, are able to produce α-defensins, underlining that their innate defense system is already active before the at-term delivery date." @default.
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• W1987707941 date "2010-08-01" @default.
• W1987707941 modified "2023-10-18" @default.
• W1987707941 title "Correlation of Levels of α–Defensins Determined by HPLC-ESI-MS in Bronchoalveolar Lavage Fluid With the Diagnosis of Pneumonia in Premature Neonates" @default.
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• W1987707941 doi "https://doi.org/10.1203/pdr.0b013e3181e5c242" @default.
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