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• W1987711769 abstract "<b><i>Background:</i></b> Clinical and epidemiological studies indicate that obstructive sleep apnea syndrome (OSAS) has a strong genetic basis. <b><i>Objectives:</i></b> To investigate the apolipoprotein E (APOE) alleles as a genetic risk factor in OSAS. <b><i>Methods:</i></b> A total of 73 patients (37 male) were included. All underwent full-night polysomnography and were evaluated for APOE alleles. <b><i>Results:</i></b> The mean age was 51 ± 12 years. Forty-two of the patients had OSAS. The APOE3 allele was found in 97.3% (71/73) of the study population. The most common APOE genotype was E3/E3 (55/73, 75.3%). Compared to the individuals with no APOE2 alleles (E3/E3, E3/E4), the individuals with at least one APOE2 allele (E2/E3, E2/E4) had a 9.37-fold greater OSAS risk (OR = 9.37, 95% CI 1.13-77.7, p = 0.019). The individuals with APOE2 alleles (E2/E3, E2/E4) compared to the individuals with only an E3/E3 allele genotype had a 10-fold greater OSAS risk (OR = 10.3, 95% CI 1.24-86.61, p = 0.0308). Compared to the individuals with no APOE4 alleles (E2/E3, E3/E3), the individuals with APOE4 alleles (E2/E4, E3/E4) had a high but insignificant risk for OSAS (OR = 2.9, 95% CI 0.55-15.05, p = 0.286). The individuals with APOE4 alleles (E2/E4, E3/E4) compared to APOE3 alleles (E3/E3) had an increased but insignificant risk for OSAS (OR = 3.62, 95% CI 0.96-19.05, p = 0.127). <b><i>Conclusion:</i></b> Specific APOE genotypes are associated with OSAS in a high-risk population." @default.
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• W1987711769 date "2015-01-01" @default.
• W1987711769 modified "2023-09-30" @default.
• W1987711769 title "The Relationship between Obstructive Sleep Apnea Syndrome and Apolipoprotein E Genetic Variants" @default.
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• W1987711769 doi "https://doi.org/10.1159/000369560" @default.
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