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- W1987716418 abstract "Conscious sheep acclimatizing to hypoxia (PaO2 40 mm Hg, PaCO2 24 mm Hg) respond with increases in cardiac output (Q̇co) and cerebral blood flow lasting for 24 and 48 h, respectively. Coronary flow increases ini a sustained fashion, while there are progressive decrease in renal, splenic and pancreatic flows. In the present study, 5 adult ewes were exposed to similar levels of normobaric hypoxia (PaO2 40 mm Hg) but the PaCO2 was maintained at eucapnic levels (32 mm Hg). V̇E increased (+210%) while V̇O2 decreased by 35%. Ventilatory sensitivity to CO2 was unchanged. Ȯco (thermodiluation) was elevated for 96 h (+20%) as stroke volume was maintained at normoxic levels and heart rate increased (+36%). Pulmonary artery pressure increased (+35%) along with plasma catecholamine levels (+116–196%). There were sustained elevations of cerebral flow (radiolabelled microspheres) from 79.1 (±9.2 SEM) to 121.6 ml·min−1·100 g−1 (±10.8), coronary flow from 183 (±22.1) to 373 ml·min−1·100 g−1 (±46.3), diaphragm flow (+400%) and intercostal muscle flow (+186%) with no apparent redistribution of Ċco. Therefore, the cardiac and peripheral circulatory response pattern are altered significantly in eucapnic hypoxia. The rate of O2 delivery to brain and several abdominal viscera is higher." @default.
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- W1987716418 date "1985-02-01" @default.
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- W1987716418 title "Peripheral circulatory responses to 96 hours of eucapnic hypoxia in conscious sheep" @default.
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- W1987716418 doi "https://doi.org/10.1016/0034-5687(85)90007-6" @default.
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