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- W1987721000 abstract "Enterostatin, the procolipase activation peptide, has been suggested in previous studies to act as a satiety signal for food intake, with a specificity for fat intake. In this study, by use of a competitive enzymelinked immunosorbent assay with a detection limit of 4.1 15 nmol/L and within 6% intra- and interassay variation, the immunoreactive and chromatographic characterization of enterostatin in intestinal content was undertaken in Sprague-Dawley rats. Following intravenous infusion of cholecystokinin octapeptide (CCK-8; 200 pmol/ kgh) for 60 min, the concentration of intestinal enterostatin increased from a basal level of 2.0 ± 0.7 KM to 5.64 ± 1.1 μM at time point 60 min. The enterostatin level remained at 4.24 ± 0.54 μM for 120 min after the CCK infusion had ceased. Pancreatic lipase and colipase activities in rat intestinal content also increased during the CCK-8 infusion. The enzyme activities reached the maximal level after 30 min of CCK infusion and thereafter progressively decreased to basal levels, remaining there during the following 2 h. The basal level of intestinal enterostatin in rats fed with standard pellets was found to be increased from 1.42 ± 0.14 to 3.86 ± 0.4,3.17 k 0.54, and 5.02 ± 1.6 FM on days 1, 3, and 7, respectively, after high-fat feeding. Parallel to the increase in intestinal enterostatin, there was a significant increase in pancreatic lipase and colipase activities in the intestine during the ingestion period of high-fat diet as compared with the control group. The estimated molecular mass of enterostatin immunoreactivity of intestinal content was similar to that of the synthetic pentapeptide. These results suggest that immunoreactive enterostatin (Val-Pro-Gly- Pro-Arg) is normally present in rat intestinal content, is significantly increased after stimulation with CCK-8, and is also increased after prolonged high-fat feeding." @default.
- W1987721000 created "2016-06-24" @default.
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- W1987721000 date "1993-07-01" @default.
- W1987721000 modified "2023-10-18" @default.
- W1987721000 title "Identification of Enterostatin, the Pancreatic Procolipase Activation Peptide in the Intestine of Rat" @default.
- W1987721000 doi "https://doi.org/10.1097/00006676-199307000-00013" @default.
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