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- W1987735346 abstract "Abstract Protein targeting by the signal recognition particle (SRP) is universally conserved and starts with the recognition of a signal sequence in the context of a translating ribosome. SRP54 and FtsY, two multidomain proteins with guanosine triphosphatase (GTPase) activity, are the central elements of the SRP system. They have to coordinate the presence of a signal sequence with the presence of a vacant translocation channel in the membrane. For coordination the two GTPases form a unique, nearly symmetric heterodimeric complex in which the activation of GTP hydrolysis plays a key role for membrane insertion of substrate proteins. Recent results are integrated in an updated perception of the order of events in SRP-mediated protein targeting." @default.
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- W1987735346 date "2009-06-27" @default.
- W1987735346 modified "2023-10-15" @default.
- W1987735346 title "Protein targeting by the signal recognition particle" @default.
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- W1987735346 doi "https://doi.org/10.1515/bc.2009.102" @default.
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