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• W1987735963 abstract "RNA polymerase recognizes its promoters through base-specific interaction between defined segments of DNA and the σ subunit of the enzyme. This interaction leads to separation of base pairs and exposure of the template strand for RNA synthesis. We show that base-specific recognition by the σ70 holoenzyme in this process involves primarily nontemplate strand bases in the −10 promoter region. We suggest that melting involves the persistence of these contacts as the bound duplex (closed) form is converted to the single-stranded (open) form of the enzyme-promoter complex." @default.
• W1987735963 created "2016-06-24" @default.
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• W1987735963 date "1996-08-01" @default.
• W1987735963 modified "2023-10-17" @default.
• W1987735963 title "Base-Specific Recognition of the Nontemplate Strand of Promoter DNA by E. coli RNA Polymerase" @default.
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• W1987735963 doi "https://doi.org/10.1016/s0092-8674(00)80122-1" @default.
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