FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987737403> ?p ?o ?g. }

• W1987737403 abstract "You have accessJournal of UrologyProstate Cancer: Basic Research III1 Apr 2014MP41-02 CLINICAL AND PATHOLOGIC CHARACTERIZATION OF ERG EXPRESSION AND TESTOSTERONE IN AFRICAN AMERICANS Michael Degon, Denise Young, Yongmei Chen, Gyorgy Petrovics, Jennifer Cullen, Jacob Kagan, Sudhir Srivastava, David McLeod, Albert Dobi, Isabell Sesterhenn, and Shiv Srivastava Michael DegonMichael Degon More articles by this author , Denise YoungDenise Young More articles by this author , Yongmei ChenYongmei Chen More articles by this author , Gyorgy PetrovicsGyorgy Petrovics More articles by this author , Jennifer CullenJennifer Cullen More articles by this author , Jacob KaganJacob Kagan More articles by this author , Sudhir SrivastavaSudhir Srivastava More articles by this author , David McLeodDavid McLeod More articles by this author , Albert DobiAlbert Dobi More articles by this author , Isabell SesterhennIsabell Sesterhenn More articles by this author , and Shiv SrivastavaShiv Srivastava More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.1219AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail Introduction and Objectives African-American men are more likely to be diagnosed with prostate cancer and more likely to die from prostate cancer then Caucasian Americans prompting intense research for determining causal molecular alterations. In recent years substantial progress has been made in defining the causal role and prevalence of ERG oncogene in prostate tumorigenesis. However, only limited number of studies has examined the frequencies of ERG in African American prostate cancer cases. The objective of the current study is to determine ERG oncoprotein frequencies and correlation with patient demographics, tumor pathology, cancer progression, and biochemical recurrence in prostatectomy specimens of African-American men. Methods In this study we have included hormone naïve African-American prostate cancer patients presenting for radical prostatectomy at a single institution over an 18 year period with 2 years of follow up. Whole-mounted radical prostatectomy specimens from 306 African-American men were evaluated by immunohistochemistry with the mouse monoclonal anti-ERG antibody, 9FY. These results were then correlated with clinical and pathologic variables. Results Consistent with previous reports from our laboratory and from others, frequencies of ERG oncoprotein were 26% in index tumors and 48% when any tumors were ERG positive in a whole-mounted section. We have found that ERG positive tumors were more likely present in younger African-American men. ERG positive tumors were significantly enriched in lower grade tumors, and ERG positive tumors correlated with higher testosterone levels. Conclusions ERG positivity of index tumors correlates with higher testosterone levels and younger age at radical prostatectomy in African-Americans. Furthermore, higher nuclear grade is more frequent in ERG positive tumors. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e450-e451 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Michael Degon More articles by this author Denise Young More articles by this author Yongmei Chen More articles by this author Gyorgy Petrovics More articles by this author Jennifer Cullen More articles by this author Jacob Kagan More articles by this author Sudhir Srivastava More articles by this author David McLeod More articles by this author Albert Dobi More articles by this author Isabell Sesterhenn More articles by this author Shiv Srivastava More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
• W1987737403 created "2016-06-24" @default.
• W1987737403 creator A5007664700 @default.
• W1987737403 creator A5015632167 @default.
• W1987737403 creator A5030027438 @default.
• W1987737403 creator A5032893111 @default.
• W1987737403 creator A5032989837 @default.
• W1987737403 creator A5036070371 @default.
• W1987737403 creator A5061944226 @default.
• W1987737403 creator A5078111669 @default.
• W1987737403 creator A5079043204 @default.
• W1987737403 creator A5087377003 @default.
• W1987737403 creator A5091150805 @default.
• W1987737403 date "2014-04-01" @default.
• W1987737403 modified "2023-09-25" @default.
• W1987737403 title "MP41-02 CLINICAL AND PATHOLOGIC CHARACTERIZATION OF ERG EXPRESSION AND TESTOSTERONE IN AFRICAN AMERICANS" @default.
• W1987737403 doi "https://doi.org/10.1016/j.juro.2014.02.1219" @default.
• W1987737403 hasPublicationYear "2014" @default.
• W1987737403 type Work @default.
• W1987737403 sameAs 1987737403 @default.
• W1987737403 citedByCount "0" @default.
• W1987737403 crossrefType "journal-article" @default.
• W1987737403 hasAuthorship W1987737403A5007664700 @default.
• W1987737403 hasAuthorship W1987737403A5015632167 @default.
• W1987737403 hasAuthorship W1987737403A5030027438 @default.
• W1987737403 hasAuthorship W1987737403A5032893111 @default.
• W1987737403 hasAuthorship W1987737403A5032989837 @default.
• W1987737403 hasAuthorship W1987737403A5036070371 @default.
• W1987737403 hasAuthorship W1987737403A5061944226 @default.
• W1987737403 hasAuthorship W1987737403A5078111669 @default.
• W1987737403 hasAuthorship W1987737403A5079043204 @default.
• W1987737403 hasAuthorship W1987737403A5087377003 @default.
• W1987737403 hasAuthorship W1987737403A5091150805 @default.
• W1987737403 hasConcept C103796816 @default.
• W1987737403 hasConcept C118487528 @default.
• W1987737403 hasConcept C121608353 @default.
• W1987737403 hasConcept C126322002 @default.
• W1987737403 hasConcept C2779279991 @default.
• W1987737403 hasConcept C2780192828 @default.
• W1987737403 hasConcept C2780827179 @default.
• W1987737403 hasConcept C555283112 @default.
• W1987737403 hasConcept C71924100 @default.
• W1987737403 hasConcept C74909509 @default.
• W1987737403 hasConceptScore W1987737403C103796816 @default.
• W1987737403 hasConceptScore W1987737403C118487528 @default.
• W1987737403 hasConceptScore W1987737403C121608353 @default.
• W1987737403 hasConceptScore W1987737403C126322002 @default.
• W1987737403 hasConceptScore W1987737403C2779279991 @default.
• W1987737403 hasConceptScore W1987737403C2780192828 @default.
• W1987737403 hasConceptScore W1987737403C2780827179 @default.
• W1987737403 hasConceptScore W1987737403C555283112 @default.
• W1987737403 hasConceptScore W1987737403C71924100 @default.
• W1987737403 hasConceptScore W1987737403C74909509 @default.
• W1987737403 hasIssue "4S" @default.
• W1987737403 hasLocation W19877374031 @default.
• W1987737403 hasOpenAccess W1987737403 @default.
• W1987737403 hasPrimaryLocation W19877374031 @default.
• W1987737403 hasRelatedWork W2030238110 @default.
• W1987737403 hasRelatedWork W2062393202 @default.
• W1987737403 hasRelatedWork W2072620890 @default.
• W1987737403 hasRelatedWork W2087654385 @default.
• W1987737403 hasRelatedWork W2107023460 @default.
• W1987737403 hasRelatedWork W2157734136 @default.
• W1987737403 hasRelatedWork W2159799721 @default.
• W1987737403 hasRelatedWork W2414643564 @default.
• W1987737403 hasRelatedWork W2895347925 @default.
• W1987737403 hasRelatedWork W3211293147 @default.
• W1987737403 hasVolume "191" @default.
• W1987737403 isParatext "false" @default.
• W1987737403 isRetracted "false" @default.
• W1987737403 magId "1987737403" @default.
• W1987737403 workType "article" @default.