FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987738861> ?p ?o ?g. }

• W1987738861 endingPage "359" @default.
• W1987738861 startingPage "353" @default.
• W1987738861 abstract "Antimicrobial peptides are multifunctional effector molecules of innate immunity. In this study we investigated whether endothelial cells actively contribute to innate defense mechanisms by expression of antimicrobial peptides. We therefore stimulated human umbilical vein endothelial cells (HUVEC) with inflammatory cytokines, Th17 cytokines, heat-inactivated bacteria, bacterial conditioned medium (BCM) of Staphylococcus aureus and Streptococcus sanguinis, and lipoteichoic acid (LTA). Stimulation with single cytokines induced discrete expression of human β-defensin 3 (hBD3) by IFN-γ or IL-1β and of ribonuclease 7 (RNase7) by TNF-α without any effects on LL-37 gene expression. Stronger hBD3 and RNase7 induction was observed after combined stimulation with IL-1β, TNF-α and IFN-γ and was confirmed by high hBD3 and RNase7 peptide levels in cell culture supernatants. In contrast, Th17 cytokines or stimulation with LTA did not result in AMP production. Moreover, only BCM of an invasive S. aureus bacteremia isolate induced hBD3 in HUVEC. We conclude that endothelial cells actively contribute to prevent dissemination of pathogens at the blood-tissue-barrier by production of AMPs that exhibit microbicidal and immunomodulatory functions. Further investigations should focus on tissue-specific AMP induction in different endothelial cell types, on pathogen-specific induction patterns and potentially involved pattern-recognition receptors of endothelial cells." @default.
• W1987738861 created "2016-06-24" @default.
• W1987738861 creator A5003702497 @default.
• W1987738861 creator A5020135122 @default.
• W1987738861 creator A5053302760 @default.
• W1987738861 creator A5073851794 @default.
• W1987738861 creator A5083991053 @default.
• W1987738861 date "2015-05-01" @default.
• W1987738861 modified "2023-10-18" @default.
• W1987738861 title "The innate defense antimicrobial peptides hBD3 and RNase7 are induced in human umbilical vein endothelial cells by classical inflammatory cytokines but not Th17 cytokines" @default.
• W1987738861 cites W1964523952 @default.
• W1987738861 cites W1975877002 @default.
• W1987738861 cites W1976896966 @default.
• W1987738861 cites W1985879208 @default.
• W1987738861 cites W1987723485 @default.
• W1987738861 cites W1994810974 @default.
• W1987738861 cites W2013588152 @default.
• W1987738861 cites W2014127446 @default.
• W1987738861 cites W2019175181 @default.
• W1987738861 cites W2056893557 @default.
• W1987738861 cites W2063236058 @default.
• W1987738861 cites W2073185462 @default.
• W1987738861 cites W2077590888 @default.
• W1987738861 cites W2080139795 @default.
• W1987738861 cites W2084942411 @default.
• W1987738861 cites W2086311760 @default.
• W1987738861 cites W2089175291 @default.
• W1987738861 cites W2089466202 @default.
• W1987738861 cites W2089559505 @default.
• W1987738861 cites W2090042814 @default.
• W1987738861 cites W2093412162 @default.
• W1987738861 cites W2095837425 @default.
• W1987738861 cites W2107086640 @default.
• W1987738861 cites W2126681871 @default.
• W1987738861 cites W2141987596 @default.
• W1987738861 cites W2142264873 @default.
• W1987738861 cites W2912349604 @default.
• W1987738861 cites W7040100 @default.
• W1987738861 doi "https://doi.org/10.1016/j.micinf.2015.01.005" @default.
• W1987738861 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25637949" @default.
• W1987738861 hasPublicationYear "2015" @default.
• W1987738861 type Work @default.
• W1987738861 sameAs 1987738861 @default.
• W1987738861 citedByCount "14" @default.
• W1987738861 countsByYear W19877388612015 @default.
• W1987738861 countsByYear W19877388612016 @default.
• W1987738861 countsByYear W19877388612017 @default.
• W1987738861 countsByYear W19877388612018 @default.
• W1987738861 countsByYear W19877388612019 @default.
• W1987738861 countsByYear W19877388612020 @default.
• W1987738861 countsByYear W19877388612021 @default.
• W1987738861 countsByYear W19877388612022 @default.
• W1987738861 crossrefType "journal-article" @default.
• W1987738861 hasAuthorship W1987738861A5003702497 @default.
• W1987738861 hasAuthorship W1987738861A5020135122 @default.
• W1987738861 hasAuthorship W1987738861A5053302760 @default.
• W1987738861 hasAuthorship W1987738861A5073851794 @default.
• W1987738861 hasAuthorship W1987738861A5083991053 @default.
• W1987738861 hasConcept C123012128 @default.
• W1987738861 hasConcept C129437159 @default.
• W1987738861 hasConcept C136449434 @default.
• W1987738861 hasConcept C164027704 @default.
• W1987738861 hasConcept C17991360 @default.
• W1987738861 hasConcept C202751555 @default.
• W1987738861 hasConcept C203014093 @default.
• W1987738861 hasConcept C2776914184 @default.
• W1987738861 hasConcept C2777411675 @default.
• W1987738861 hasConcept C2778690821 @default.
• W1987738861 hasConcept C2779489039 @default.
• W1987738861 hasConcept C4937899 @default.
• W1987738861 hasConcept C523546767 @default.
• W1987738861 hasConcept C540938839 @default.
• W1987738861 hasConcept C54355233 @default.
• W1987738861 hasConcept C55493867 @default.
• W1987738861 hasConcept C6977687 @default.
• W1987738861 hasConcept C86803240 @default.
• W1987738861 hasConcept C8891405 @default.
• W1987738861 hasConcept C89423630 @default.
• W1987738861 hasConcept C95444343 @default.
• W1987738861 hasConceptScore W1987738861C123012128 @default.
• W1987738861 hasConceptScore W1987738861C129437159 @default.
• W1987738861 hasConceptScore W1987738861C136449434 @default.
• W1987738861 hasConceptScore W1987738861C164027704 @default.
• W1987738861 hasConceptScore W1987738861C17991360 @default.
• W1987738861 hasConceptScore W1987738861C202751555 @default.
• W1987738861 hasConceptScore W1987738861C203014093 @default.
• W1987738861 hasConceptScore W1987738861C2776914184 @default.
• W1987738861 hasConceptScore W1987738861C2777411675 @default.
• W1987738861 hasConceptScore W1987738861C2778690821 @default.
• W1987738861 hasConceptScore W1987738861C2779489039 @default.
• W1987738861 hasConceptScore W1987738861C4937899 @default.
• W1987738861 hasConceptScore W1987738861C523546767 @default.
• W1987738861 hasConceptScore W1987738861C540938839 @default.
• W1987738861 hasConceptScore W1987738861C54355233 @default.
• W1987738861 hasConceptScore W1987738861C55493867 @default.
• W1987738861 hasConceptScore W1987738861C6977687 @default.
• W1987738861 hasConceptScore W1987738861C86803240 @default.
• W1987738861 hasConceptScore W1987738861C8891405 @default.

• next