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• W1987739258 endingPage "1864" @default.
• W1987739258 startingPage "1843" @default.
• W1987739258 abstract "Tachykinins (TKs) are small peptides widely distributed in the central and peripheral nervous systems where they act as neurotransmitters. Potent and selective TKs antagonists have been developed in the last 20 years and many efforts have been made to prove their efficacy in the treatment of various diseases. Herein the most prominent results in the clinical development are reported and discussed. For aprepitant, the only compound of this class to have been launched to date, results of clinical studies and postmarketing cost-effectiveness data for the treatment of chemotherapy-induced emesis are discussed. The field is still well active, as currently proof-of-concept studies for indications initially missed (i.e., depression) are ongoing and new targets are under investigation." @default.
• W1987739258 created "2016-06-24" @default.
• W1987739258 creator A5023274863 @default.
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• W1987739258 creator A5057520375 @default.
• W1987739258 creator A5089436979 @default.
• W1987739258 date "2009-11-25" @default.
• W1987739258 modified "2023-10-02" @default.
• W1987739258 title "Tachykinin receptor antagonists in clinical trials" @default.
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• W1987739258 doi "https://doi.org/10.1517/13543780903379530" @default.
• W1987739258 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19938899" @default.
• W1987739258 hasPublicationYear "2009" @default.
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