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• W1987752502 endingPage "36" @default.
• W1987752502 startingPage "29" @default.
• W1987752502 abstract "The objective of this study was to determine whether functional differences exist in amphetamine-induced locomotor activity between alcohol-naive alcohol-preferring (P) and -nonpreferring (NP) rats during postnatal development and during adulthood. Using a between-subjects design, 20- and 28-day-old P and NP rats (male and female counterbalanced, n=11-16/line) were habituated for 30 min in a photocell activity field. Each rat received subcutaneous injections of saline or 0.3, 0.6 or 1.2 mg/kg d-amphetamine (AMPH) and were then tested for an additional 30 min. Because of age and line differences in basal locomotor activity, total activity counts during the 30-min postdrug period were standardized using Z-score transformations. In the 20- and 28-day-old rats, dose-dependent locomotor activity increases after AMPH injections were obtained at both ages, although activity levels were greater in the 20-day-old pups. The 20-day-old female NP rats showed greater AMPH-induced increases in locomotor activity than P rats, whereas at 28 days of age, male NP rats showed greater activity levels than P rats to AMPH. For the adult P and NP rats (n=8/line/gender), a within-subject design was used. In the adults, the NP line had higher locomotor activity than the P line following AMPH injection, and male rats were activated more by AMPH than female rats. The results suggest that functioning of the DA system in the adult P line is reduced compared to the adult NP line, and this line difference is also observed to some degree at an early postweaning developmental period." @default.
• W1987752502 created "2016-06-24" @default.
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• W1987752502 date "2002-01-01" @default.
• W1987752502 modified "2023-10-03" @default.
• W1987752502 title "Effects of amphetamine on locomotor activity in adult and juvenile alcohol-preferring and -nonpreferring rats" @default.
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• W1987752502 doi "https://doi.org/10.1016/s0091-3057(01)00610-4" @default.
• W1987752502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11812505" @default.
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