Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987773170> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W1987773170 endingPage "2090" @default.
- W1987773170 startingPage "2085" @default.
- W1987773170 abstract "The diagnostic fragmentation of N-oxides resulting from loss of the oxygen atom (MH+ --> MH+-O) in electrospray and atmospheric pressure chemical ionization (APCI) mass spectra was investigated. When the temperature of the heated capillary tube was elevated, the ratio of the intensity of the [MH+ -16] fragment to the precursor ion (MH+) increased. This 'deoxygenation' process was associated with thermal activation and did not result from collisional activation in the desolvation region of the API source. Although the extent of 'deoxygenation' is compound-dependent, it can provide evidence for the presence of an N-oxide in a sample and can be used to distinguish N-oxides from hydroxylated metabolites (Ramanathan et al. Anal. Chem. 2000; 72: 1352). To demonstrate the practical application of thermal fragmentation of N-oxides, liquid chromatography (LC)/APCI-MS was used to distinguish an N-oxide drug from its hydroxylated metabolite in an unprocessed rat urine sample, despite the fact that the drug and its metabolite were not fully resolved by HPLC." @default.
- W1987773170 created "2016-06-24" @default.
- W1987773170 creator A5001381737 @default.
- W1987773170 creator A5007216971 @default.
- W1987773170 creator A5012621958 @default.
- W1987773170 creator A5048320268 @default.
- W1987773170 creator A5067922412 @default.
- W1987773170 creator A5087802976 @default.
- W1987773170 date "2001-10-11" @default.
- W1987773170 modified "2023-10-17" @default.
- W1987773170 title "Fragmentation of N-oxides (deoxygenation) in atmospheric pressure ionization: Investigation of the activation process" @default.
- W1987773170 cites W2122439895 @default.
- W1987773170 cites W4243799879 @default.
- W1987773170 cites W4300414728 @default.
- W1987773170 doi "https://doi.org/10.1002/rcm.475" @default.
- W1987773170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11746872" @default.
- W1987773170 hasPublicationYear "2001" @default.
- W1987773170 type Work @default.
- W1987773170 sameAs 1987773170 @default.
- W1987773170 citedByCount "62" @default.
- W1987773170 countsByYear W19877731702012 @default.
- W1987773170 countsByYear W19877731702013 @default.
- W1987773170 countsByYear W19877731702014 @default.
- W1987773170 countsByYear W19877731702016 @default.
- W1987773170 countsByYear W19877731702017 @default.
- W1987773170 countsByYear W19877731702019 @default.
- W1987773170 countsByYear W19877731702020 @default.
- W1987773170 countsByYear W19877731702021 @default.
- W1987773170 countsByYear W19877731702022 @default.
- W1987773170 countsByYear W19877731702023 @default.
- W1987773170 crossrefType "journal-article" @default.
- W1987773170 hasAuthorship W1987773170A5001381737 @default.
- W1987773170 hasAuthorship W1987773170A5007216971 @default.
- W1987773170 hasAuthorship W1987773170A5012621958 @default.
- W1987773170 hasAuthorship W1987773170A5048320268 @default.
- W1987773170 hasAuthorship W1987773170A5067922412 @default.
- W1987773170 hasAuthorship W1987773170A5087802976 @default.
- W1987773170 hasConcept C111368507 @default.
- W1987773170 hasConcept C111919701 @default.
- W1987773170 hasConcept C113196181 @default.
- W1987773170 hasConcept C127313418 @default.
- W1987773170 hasConcept C145148216 @default.
- W1987773170 hasConcept C148065180 @default.
- W1987773170 hasConcept C161790260 @default.
- W1987773170 hasConcept C162356407 @default.
- W1987773170 hasConcept C178790620 @default.
- W1987773170 hasConcept C185592680 @default.
- W1987773170 hasConcept C191015642 @default.
- W1987773170 hasConcept C194451485 @default.
- W1987773170 hasConcept C198291218 @default.
- W1987773170 hasConcept C200239111 @default.
- W1987773170 hasConcept C2777477808 @default.
- W1987773170 hasConcept C2779778602 @default.
- W1987773170 hasConcept C41008148 @default.
- W1987773170 hasConcept C43617362 @default.
- W1987773170 hasConcept C51884965 @default.
- W1987773170 hasConcept C55493867 @default.
- W1987773170 hasConceptScore W1987773170C111368507 @default.
- W1987773170 hasConceptScore W1987773170C111919701 @default.
- W1987773170 hasConceptScore W1987773170C113196181 @default.
- W1987773170 hasConceptScore W1987773170C127313418 @default.
- W1987773170 hasConceptScore W1987773170C145148216 @default.
- W1987773170 hasConceptScore W1987773170C148065180 @default.
- W1987773170 hasConceptScore W1987773170C161790260 @default.
- W1987773170 hasConceptScore W1987773170C162356407 @default.
- W1987773170 hasConceptScore W1987773170C178790620 @default.
- W1987773170 hasConceptScore W1987773170C185592680 @default.
- W1987773170 hasConceptScore W1987773170C191015642 @default.
- W1987773170 hasConceptScore W1987773170C194451485 @default.
- W1987773170 hasConceptScore W1987773170C198291218 @default.
- W1987773170 hasConceptScore W1987773170C200239111 @default.
- W1987773170 hasConceptScore W1987773170C2777477808 @default.
- W1987773170 hasConceptScore W1987773170C2779778602 @default.
- W1987773170 hasConceptScore W1987773170C41008148 @default.
- W1987773170 hasConceptScore W1987773170C43617362 @default.
- W1987773170 hasConceptScore W1987773170C51884965 @default.
- W1987773170 hasConceptScore W1987773170C55493867 @default.
- W1987773170 hasIssue "22" @default.
- W1987773170 hasLocation W19877731701 @default.
- W1987773170 hasLocation W19877731702 @default.
- W1987773170 hasOpenAccess W1987773170 @default.
- W1987773170 hasPrimaryLocation W19877731701 @default.
- W1987773170 hasRelatedWork W1746909987 @default.
- W1987773170 hasRelatedWork W1812380991 @default.
- W1987773170 hasRelatedWork W1963484438 @default.
- W1987773170 hasRelatedWork W2045257719 @default.
- W1987773170 hasRelatedWork W2126429502 @default.
- W1987773170 hasRelatedWork W2157007491 @default.
- W1987773170 hasRelatedWork W2157984997 @default.
- W1987773170 hasRelatedWork W2981324898 @default.
- W1987773170 hasRelatedWork W3086778715 @default.
- W1987773170 hasRelatedWork W605993327 @default.
- W1987773170 hasVolume "15" @default.
- W1987773170 isParatext "false" @default.
- W1987773170 isRetracted "false" @default.
- W1987773170 magId "1987773170" @default.
- W1987773170 workType "article" @default.