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• W1987788844 abstract "Abstract Background The transitional-CpG sites between weakly methylated genes and densely methylated retroelements are overmethylated in the gastric mucosa infected with Helicobacter pylori ( H. pylori ) and they are undermethylated in the gastric cancers depending on the level of loss of heterozygosity (LOH) events. This study delineated the transitional-CpG methylation patterns of CpG-island-containing and -lacking genes in view of the retroelements. Methods The transitional-CpG sites of eight CpG-island-containing genes and six CpG-island-lacking genes were semi-quantitatively examined by performing radioisotope-labelling methylation-specific PCR under stringent conditions. The level of LOH in the gastric cancers was estimated using the 40 microsatellite markers on eight cancer-associated chromosomes. Each gene was scored as overmethylated or undermethylated based on an intermediate level of transitional-CpG methylation common in the H. pylori -negative gastric mucosa. Results The eight CpG-island genes examined were overmethylated depending on the proximity to the nearest retroelement in the H. pylori -positive gastric mucosa. The six CpG-island-lacking genes were similarly methylated in the H. pylori -positive and -negative gastric mucosa. In the gastric cancers, long transitional-CpG segments of the CpG-island genes distant from the retroelements remained overmethylated, whereas the overmethylation of short transitional-CpG segments close to the retroelements was not significant. Both the CpG-island-containing and -lacking genes tended to be decreasingly methylated in a LOH-level-dependent manner. Conclusions The overmethylated genes under the influence of retroelement methylation in the H. pylori -infected stomach are demethylated in the gastric cancers influenced by LOH." @default.
• W1987788844 created "2016-06-24" @default.
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• W1987788844 date "2010-11-20" @default.
• W1987788844 modified "2023-10-09" @default.
• W1987788844 title "The overmethylated genes in Helicobacter pylori-infected gastric mucosa are demethylated in gastric cancers" @default.
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• W1987788844 doi "https://doi.org/10.1186/1471-230x-10-137" @default.
• W1987788844 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2995475" @default.
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