Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987788885> ?p ?o ?g. }
- W1987788885 endingPage "244" @default.
- W1987788885 startingPage "229" @default.
- W1987788885 abstract "The p53 tumor suppressor is embedded in a large gene network controlling diverse cellular and organismal phenotypes. Multiple signaling pathways converge onto p53 activation, mostly by relieving the inhibitory effects of its repressors, MDM2 and MDM4. In turn, signals originating from increased p53 activity diverge into distinct effector pathways to deliver a specific cellular response to the activating stimuli. Much attention has been devoted to dissecting how the various input pathways trigger p53 activation and how the activity of the p53 protein itself can be modulated by a plethora of co-factors and post-translational modifications. In this review we will focus instead on the multiple configurations of the effector pathways. We will discuss how p53-generated signals are transmitted, amplified, resisted and eventually integrated by downstream gene circuits operating at the transcriptional, post-transcriptional and post-translational levels. We will also discuss how context-dependent variations in these gene circuits define the cellular response to p53 activation and how they may impact the clinical efficacy of p53-based targeted therapies." @default.
- W1987788885 created "2016-06-24" @default.
- W1987788885 creator A5007856003 @default.
- W1987788885 creator A5016618743 @default.
- W1987788885 creator A5027320272 @default.
- W1987788885 creator A5055771287 @default.
- W1987788885 creator A5060639948 @default.
- W1987788885 date "2012-04-01" @default.
- W1987788885 modified "2023-09-26" @default.
- W1987788885 title "The p53 circuit board" @default.
- W1987788885 cites W1482923899 @default.
- W1987788885 cites W1497251274 @default.
- W1987788885 cites W1520203303 @default.
- W1987788885 cites W1531240647 @default.
- W1987788885 cites W1534987406 @default.
- W1987788885 cites W1580072616 @default.
- W1987788885 cites W1650797637 @default.
- W1987788885 cites W1796960706 @default.
- W1987788885 cites W1963557326 @default.
- W1987788885 cites W1964719993 @default.
- W1987788885 cites W1964742508 @default.
- W1987788885 cites W1965233827 @default.
- W1987788885 cites W1965444422 @default.
- W1987788885 cites W1965978028 @default.
- W1987788885 cites W1966163762 @default.
- W1987788885 cites W1969385456 @default.
- W1987788885 cites W1971166655 @default.
- W1987788885 cites W1971563492 @default.
- W1987788885 cites W1972263121 @default.
- W1987788885 cites W1972476934 @default.
- W1987788885 cites W1973049520 @default.
- W1987788885 cites W1973570584 @default.
- W1987788885 cites W1975206161 @default.
- W1987788885 cites W1976091143 @default.
- W1987788885 cites W1976764293 @default.
- W1987788885 cites W1977258127 @default.
- W1987788885 cites W1978259246 @default.
- W1987788885 cites W1978406914 @default.
- W1987788885 cites W1979206664 @default.
- W1987788885 cites W1981178222 @default.
- W1987788885 cites W1981700349 @default.
- W1987788885 cites W1981703479 @default.
- W1987788885 cites W1982081546 @default.
- W1987788885 cites W1982259691 @default.
- W1987788885 cites W1984247920 @default.
- W1987788885 cites W1985064409 @default.
- W1987788885 cites W1986179131 @default.
- W1987788885 cites W1986384390 @default.
- W1987788885 cites W1987520716 @default.
- W1987788885 cites W1991734748 @default.
- W1987788885 cites W1993263392 @default.
- W1987788885 cites W1994015824 @default.
- W1987788885 cites W1995095999 @default.
- W1987788885 cites W1995773170 @default.
- W1987788885 cites W1995856480 @default.
- W1987788885 cites W1997054509 @default.
- W1987788885 cites W1998068165 @default.
- W1987788885 cites W2000612933 @default.
- W1987788885 cites W2004273407 @default.
- W1987788885 cites W2005893109 @default.
- W1987788885 cites W2007232912 @default.
- W1987788885 cites W2008416692 @default.
- W1987788885 cites W2008715871 @default.
- W1987788885 cites W2009554628 @default.
- W1987788885 cites W2010697949 @default.
- W1987788885 cites W2014847481 @default.
- W1987788885 cites W2014938226 @default.
- W1987788885 cites W2015519364 @default.
- W1987788885 cites W2015619266 @default.
- W1987788885 cites W2015680924 @default.
- W1987788885 cites W2018385269 @default.
- W1987788885 cites W2018884388 @default.
- W1987788885 cites W2019573405 @default.
- W1987788885 cites W2020630430 @default.
- W1987788885 cites W2021129338 @default.
- W1987788885 cites W2021724838 @default.
- W1987788885 cites W2023364012 @default.
- W1987788885 cites W2024996523 @default.
- W1987788885 cites W2025122502 @default.
- W1987788885 cites W2028553570 @default.
- W1987788885 cites W2029350002 @default.
- W1987788885 cites W2030331321 @default.
- W1987788885 cites W2031100736 @default.
- W1987788885 cites W2033787070 @default.
- W1987788885 cites W2036521316 @default.
- W1987788885 cites W2038725955 @default.
- W1987788885 cites W2044057392 @default.
- W1987788885 cites W2045047786 @default.
- W1987788885 cites W2045086385 @default.
- W1987788885 cites W2046254929 @default.
- W1987788885 cites W2047242201 @default.
- W1987788885 cites W2048595515 @default.
- W1987788885 cites W2049462796 @default.
- W1987788885 cites W2049527615 @default.
- W1987788885 cites W2050467335 @default.
- W1987788885 cites W2050795774 @default.
- W1987788885 cites W2051000382 @default.
- W1987788885 cites W2051113417 @default.