FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987789273> ?p ?o ?g. }

• W1987789273 endingPage "389" @default.
• W1987789273 startingPage "380" @default.
• W1987789273 abstract "Autoantibodies directed against neutrophil cytoplasmic antigens (ANCA) are valuable in the diagnosis of primary systemic vasculitis, and immunofluorescence studies suggest that changes in ANCA concentration reflect changes in disease activity. We used enzyme-linked immunosorbent assays to examine retrospectively the relationship between ANCA concentration and disease activity in 56 patients with systemic vasculitis. We included patients with Wegener's granulomatosis, microscopic polyangiitis, idiopathic rapidly progressive glomerulonephritis, and Churg-Strauss syndrome, and examined separately the initial treatment period (mean length of follow-up, 26 months) and long-term management (mean length of follow-up, 59 months). Levels of ANCA decreased during induction therapy with prednisolone and cyclophosphamide, with or without plasma exchange. During follow-up, 27 relapses were documented in 20 patients (10 with Wegener's granulomatosis, nine with microscopic polyangiitis, and one with Churg-Strauss syndrome), occurring between 4 and 183 months (mean, 62 months) after initial presentation. Patients in whom ANCA were detectable 1 year or more after treatment were at particular risk of clinical relapse. Proteinase 3-directed ANCA appeared to be associated with a higher rate of relapse (44% of patients relapsed) than myeloperoxidase-directed ANCA (13% of patients relapsed). Twenty-four of the 27 relapses occurred in the presence of detectable ANCA; in 21 of these, ANCA concentration was high or rising. The temporal relationship between changes in ANCA concentration and clinical relapse varied considerably between patients; in seven patients, ANCA remained at high levels for many months (range, 14 to 67 months) before eventual relapse. One patient showed high concentrations of ANCA over a period of 11 years without relapse. In five patients, increases in the ANCA level were not temporally associated with relapse (although four of these patients relapsed on other occasions.) We conclude that monitoring ANCA by enzyme-linked immunosorbent assays is of value in the long-term management of patients with Wegener's granulomatosis, micr oscopic polyangiitis, idiopathic rapidly progressive glomerulonephritis, and Churg-Strauss syndrome. Increases in ANCA and persistently high levels point to the risk of relapse and indicate the need for frequent clinical review and continuing maintenance immunosuppression. However, our results suggest that ANCA assays should always be used in conjunction with other indices of disease activity and should not be the sole basis for changing therapy." @default.
• W1987789273 created "2016-06-24" @default.
• W1987789273 creator A5016127446 @default.
• W1987789273 creator A5018952212 @default.
• W1987789273 creator A5048416393 @default.
• W1987789273 creator A5054024077 @default.
• W1987789273 creator A5083988430 @default.
• W1987789273 date "1995-03-01" @default.
• W1987789273 modified "2023-10-01" @default.
• W1987789273 title "Relationship between disease activity and anti-neutrophil cytoplasmic antibody concentration in long-term management of systemic vasculitis" @default.
• W1987789273 cites W1966674260 @default.
• W1987789273 cites W1968808508 @default.
• W1987789273 cites W1972402866 @default.
• W1987789273 cites W1976665952 @default.
• W1987789273 cites W1977894685 @default.
• W1987789273 cites W1987806264 @default.
• W1987789273 cites W1999410613 @default.
• W1987789273 cites W2004860183 @default.
• W1987789273 cites W2038625439 @default.
• W1987789273 cites W2039582264 @default.
• W1987789273 cites W2045911949 @default.
• W1987789273 cites W2052968750 @default.
• W1987789273 cites W2055890849 @default.
• W1987789273 cites W2056977206 @default.
• W1987789273 cites W2070018038 @default.
• W1987789273 cites W2083777349 @default.
• W1987789273 cites W2086183699 @default.
• W1987789273 cites W2097866139 @default.
• W1987789273 cites W2100936098 @default.
• W1987789273 cites W2109207289 @default.
• W1987789273 cites W2137676749 @default.
• W1987789273 cites W2151063782 @default.
• W1987789273 cites W2153013281 @default.
• W1987789273 cites W2162725007 @default.
• W1987789273 cites W2170737062 @default.
• W1987789273 cites W2315629778 @default.
• W1987789273 cites W2902766594 @default.
• W1987789273 doi "https://doi.org/10.1016/0272-6386(95)90098-5" @default.
• W1987789273 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7872315" @default.
• W1987789273 hasPublicationYear "1995" @default.
• W1987789273 type Work @default.
• W1987789273 sameAs 1987789273 @default.
• W1987789273 citedByCount "122" @default.
• W1987789273 countsByYear W19877892732012 @default.
• W1987789273 countsByYear W19877892732013 @default.
• W1987789273 countsByYear W19877892732014 @default.
• W1987789273 countsByYear W19877892732015 @default.
• W1987789273 countsByYear W19877892732016 @default.
• W1987789273 countsByYear W19877892732017 @default.
• W1987789273 countsByYear W19877892732018 @default.
• W1987789273 countsByYear W19877892732020 @default.
• W1987789273 countsByYear W19877892732021 @default.
• W1987789273 countsByYear W19877892732022 @default.
• W1987789273 countsByYear W19877892732023 @default.
• W1987789273 crossrefType "journal-article" @default.
• W1987789273 hasAuthorship W1987789273A5016127446 @default.
• W1987789273 hasAuthorship W1987789273A5018952212 @default.
• W1987789273 hasAuthorship W1987789273A5048416393 @default.
• W1987789273 hasAuthorship W1987789273A5054024077 @default.
• W1987789273 hasAuthorship W1987789273A5083988430 @default.
• W1987789273 hasConcept C126322002 @default.
• W1987789273 hasConcept C159654299 @default.
• W1987789273 hasConcept C163764329 @default.
• W1987789273 hasConcept C203014093 @default.
• W1987789273 hasConcept C21194631 @default.
• W1987789273 hasConcept C24040308 @default.
• W1987789273 hasConcept C2775998817 @default.
• W1987789273 hasConcept C2776015282 @default.
• W1987789273 hasConcept C2776694085 @default.
• W1987789273 hasConcept C2776715498 @default.
• W1987789273 hasConcept C2776755627 @default.
• W1987789273 hasConcept C2777374719 @default.
• W1987789273 hasConcept C2778910314 @default.
• W1987789273 hasConcept C2779134260 @default.
• W1987789273 hasConcept C2780091579 @default.
• W1987789273 hasConcept C2780368995 @default.
• W1987789273 hasConcept C2781229154 @default.
• W1987789273 hasConcept C71924100 @default.
• W1987789273 hasConcept C90924648 @default.
• W1987789273 hasConceptScore W1987789273C126322002 @default.
• W1987789273 hasConceptScore W1987789273C159654299 @default.
• W1987789273 hasConceptScore W1987789273C163764329 @default.
• W1987789273 hasConceptScore W1987789273C203014093 @default.
• W1987789273 hasConceptScore W1987789273C21194631 @default.
• W1987789273 hasConceptScore W1987789273C24040308 @default.
• W1987789273 hasConceptScore W1987789273C2775998817 @default.
• W1987789273 hasConceptScore W1987789273C2776015282 @default.
• W1987789273 hasConceptScore W1987789273C2776694085 @default.
• W1987789273 hasConceptScore W1987789273C2776715498 @default.
• W1987789273 hasConceptScore W1987789273C2776755627 @default.
• W1987789273 hasConceptScore W1987789273C2777374719 @default.
• W1987789273 hasConceptScore W1987789273C2778910314 @default.
• W1987789273 hasConceptScore W1987789273C2779134260 @default.
• W1987789273 hasConceptScore W1987789273C2780091579 @default.
• W1987789273 hasConceptScore W1987789273C2780368995 @default.
• W1987789273 hasConceptScore W1987789273C2781229154 @default.
• W1987789273 hasConceptScore W1987789273C71924100 @default.
• W1987789273 hasConceptScore W1987789273C90924648 @default.

• next