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- W1987839026 abstract "Previous studies have suggested that macrophage migration inhibitory factor (MIF) may play a critical role in the pathogenesis of Guillain–Barre syndrome (GBS); however, its definite mechanism remains unknown. In this study, we prepared the monocytes from the peripheral blood mononuclear cells (PBMCs) of GBS patients and the controls. Lipo-oligosaccharide (LOS) from Campylobacter jejuni was used as the stimulus of the monocytes in vitro and siRNA–MIF was used to explore the roles of MIF in LOS-induced response. Significantly, silencing of MIF attenuated the LOS-induced up-regulation of Toll-like receptor 4 (TLR4) and translocation of NF-кB into the nucleus; we also observed the up-regulation of IL-12p40, TNF-α, IL-6, CXCL8 and CCL5 in GBS monocytes with LOS stimulus; and siRNA–MIF overrided the effects of LOS on the production of the TNF-α, IL-6, and CXCL8. Conclusively, our study provides evidences that MIF may participate in the pathogenesis of GBS by modulating the LOS-induced response through TLR4 signaling pathway." @default.
- W1987839026 created "2016-06-24" @default.
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- W1987839026 date "2013-04-01" @default.
- W1987839026 modified "2023-10-16" @default.
- W1987839026 title "Macrophage migration inhibitory factor is necessary for the Lipo-oligosaccharide-induced response by modulation of Toll-like receptor 4 in monocytes from GBS patients" @default.
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- W1987839026 doi "https://doi.org/10.1016/j.jneuroim.2013.01.006" @default.
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