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- W1987840479 abstract "Abstract The first approach to antibodies with enzymatic activity in pyrophosphates is to find water-stable haptens which could show potential as substrates or inhibitors against phosphorolytic enzymes. In the simple case (competitive agents) this requires design of stable phosphoranes with a trigonal-bipyramidal structure such as in some fluorine-substituted phosphoranes. We established that the interatomic distances pattern in bipyramid residues is more suitable for the molecules II and III when the MMX calculations (PCMODEL program, N. Allinger) of Mg ++ — diphosphate (MgPP; I-transition state for the inorganic yeast pyrophosphatase substrate) and some model synthetic compounds were made. Correlation coefficients between interatomic distances in bipyramids for I–II and I–III pairs are 0.991 and 0.921 respectively. Compounds II and III were synthesized by our method. Anti-enzymatic activity was studied with MgPP as substrate. Compound II was more active than III, as expected, and both showed activities as syncatalithic inhibitors. Constant of the pseudo-irreversible inhibition for II is 1.2×10 7 M −1 min −1 ." @default.
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- W1987840479 date "1992-08-01" @default.
- W1987840479 modified "2023-09-23" @default.
- W1987840479 title "Design, synthesis and anti-enzymatic activity of novel water-stable fluorine-containing phosphoranes" @default.
- W1987840479 doi "https://doi.org/10.1016/s0022-1139(00)80648-x" @default.
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