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- W1987842132 abstract "Abstract 2-Deaminoactinomycin D ( 3a ) and 2-deamino-2-nitroactinomycin D ( 2a ) were prepared in one step from actinomycin D ( 1a , AMD) by reaction with nitrous acid. New DNA-binding (calf-thymus) data obtained by difference uv and CD spectra and Δ Tm were presented. In vitro cell growth inhibitory activity of CCRF-CEM cells was also reported. The 2-deamino analog, 3a , does not bind to DNA strongly nor by intercalation of its chromophore. However, some binding with DNA was indicated by CD which is attributed only to hydrogen bondings of the peptides with the DNA helix; the affinity for binding is in the order 1a ⪢ 2a > 3a . The 2-nitro analog, 2a , is a more potent agent against CCRF-CEM cells than the 2-deaminoactinomycin D, 3a ; the potencies are in the order 1a > 2a ⪢ 3a . Furthermore, the microsomes activate the analogs to free radical states which catalyze the production of superoxide, as indicated by electron paramagnetic resonance studies and oxygen consumption experiments." @default.
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- W1987842132 date "1985-06-01" @default.
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- W1987842132 title "Interaction of 2-deamino- and 2-deamino-2-nitroactinomycin D with calf-thymus DNA and formation of ion-radicals" @default.
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- W1987842132 doi "https://doi.org/10.1016/0045-2068(85)90013-6" @default.
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