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• W1987843669 abstract "Pregnant rats were treated daily with haloperidol (2 mg/kg) for 11 days until 1 day before birth. The levels of nerve growth factor (NGF), its receptor (NGFR) and NGFR-mRNA were measured in forebrain of 2-day old postnatal rats. Using Northern blot analysis, we observed a decrease in NGFR-mRNA. Furthermore, in binding studies, K d and B max of treated rats were lower than in controls, but only in the low affinity binding sites. However NGF and its mRNA did not change after haloperidol treatment. In conclusion, our results suggest that prenatal haloperidol treatment can modify the development of forebrain cells, by changing NGFR expression." @default.
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• W1987843669 date "1991-10-01" @default.
• W1987843669 modified "2023-10-12" @default.
• W1987843669 title "Prenatal haloperidol treatment decreases nerve growth factor receptor and mRNA in neonate rat forebrain" @default.
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• W1987843669 doi "https://doi.org/10.1016/0304-3940(91)90620-9" @default.
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