FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987869069> ?p ?o ?g. }

• W1987869069 endingPage "2056" @default.
• W1987869069 startingPage "2047" @default.
• W1987869069 abstract "STMN1 (stathmin or oncoprotein-18) destabilizes microtubules and reorganizes cytoskeleton, and functions in cell cycle progression and cell migration. STMN1 activity is influenced by p53, p27, and the PI3K/AKT pathway. However, its prognostic significance in colon cancer is uncertain.Utilizing 546 colorectal cancers (stage I-IV) from two independent prospective cohort studies (the Nurses' Health Study and Health Professionals Follow-up Study), STMN1 expression was detected in 297 (54%) tumors by immunohistochemistry. Cox proportional hazard models computed hazard ratios (HRs) of mortality, adjusted for clinical and tumoral features, including microsatellite instability (MSI), CpG island methylation phenotype (CIMP), LINE-1 hypomethylation, KRAS, BRAF, PIK3CA, p53, p21, p27, cyclin D1, beta-catenin, fatty acid synthase, FASN, and COX-2.Five-year colorectal cancer-specific survival was 78% in STMN1-positive patients and 76% in STMN1-negative patients (log-rank P=0.30). STMN1-positivity was not significantly associated with cancer-specific survival in univariate analysis with HR of 0.82 (95% confidence interval (CI), 0.59-1.14), which became significant in multivariate analysis (adjusted HR=0.60; 95% CI, 0.41-0.87; P=0.0078). Notably, the prognostic effect of obesity (body mass index, BMI> or =30 kg/m2) significantly differed by STMN1 (P(interaction)=0.005). Obesity was associated with high cancer-specific mortality among STMN1-positive patients (adjusted HR=2.36; 95% CI, 1.18-4.69), whereas obesity was not associated with high mortality among STMN1-negative patients (adjusted HR=0.51; 95% CI, 0.24-1.07).STMN1 overexpression in colorectal cancer is independently associated with improved survival. The adverse prognostic effect of obesity was limited to patients with STMN1-positive tumors. Our findings suggest the presence of a tumor (STMN1)-host (BMI) interaction that potentially determines clinical outcome." @default.
• W1987869069 created "2016-06-24" @default.
• W1987869069 creator A5001060980 @default.
• W1987869069 creator A5004733324 @default.
• W1987869069 creator A5011491566 @default.
• W1987869069 creator A5018121170 @default.
• W1987869069 creator A5037989560 @default.
• W1987869069 creator A5038373228 @default.
• W1987869069 creator A5039869228 @default.
• W1987869069 creator A5047496278 @default.
• W1987869069 creator A5049314303 @default.
• W1987869069 creator A5057394943 @default.
• W1987869069 creator A5068835941 @default.
• W1987869069 creator A5069774184 @default.
• W1987869069 creator A5076818447 @default.
• W1987869069 date "2009-06-09" @default.
• W1987869069 modified "2023-10-05" @default.
• W1987869069 title "A Cohort Study of STMN1 Expression in Colorectal Cancer: Body Mass Index and Prognosis" @default.
• W1987869069 cites W1498471683 @default.
• W1987869069 cites W1500760816 @default.
• W1987869069 cites W1510189975 @default.
• W1987869069 cites W1565350682 @default.
• W1987869069 cites W1965301144 @default.
• W1987869069 cites W1965680145 @default.
• W1987869069 cites W1971937022 @default.
• W1987869069 cites W1974574293 @default.
• W1987869069 cites W1975233292 @default.
• W1987869069 cites W1984621921 @default.
• W1987869069 cites W1984824189 @default.
• W1987869069 cites W1997058261 @default.
• W1987869069 cites W1997125643 @default.
• W1987869069 cites W1997860952 @default.
• W1987869069 cites W1998677519 @default.
• W1987869069 cites W2009785870 @default.
• W1987869069 cites W2009886463 @default.
• W1987869069 cites W2011785751 @default.
• W1987869069 cites W2017513981 @default.
• W1987869069 cites W2018679072 @default.
• W1987869069 cites W2023473560 @default.
• W1987869069 cites W2029945937 @default.
• W1987869069 cites W2034122323 @default.
• W1987869069 cites W2035907443 @default.
• W1987869069 cites W2037050524 @default.
• W1987869069 cites W2037952228 @default.
• W1987869069 cites W2045354247 @default.
• W1987869069 cites W2048159798 @default.
• W1987869069 cites W2067944964 @default.
• W1987869069 cites W2069140606 @default.
• W1987869069 cites W2069663898 @default.
• W1987869069 cites W2081905918 @default.
• W1987869069 cites W2084469088 @default.
• W1987869069 cites W2085267622 @default.
• W1987869069 cites W2085618460 @default.
• W1987869069 cites W2087327978 @default.
• W1987869069 cites W2090062366 @default.
• W1987869069 cites W2092806152 @default.
• W1987869069 cites W2103663786 @default.
• W1987869069 cites W2105307866 @default.
• W1987869069 cites W2107070608 @default.
• W1987869069 cites W2110546638 @default.
• W1987869069 cites W2123636561 @default.
• W1987869069 cites W2123874208 @default.
• W1987869069 cites W2128613144 @default.
• W1987869069 cites W2134917812 @default.
• W1987869069 cites W2143000305 @default.
• W1987869069 cites W2144366590 @default.
• W1987869069 cites W2144990254 @default.
• W1987869069 cites W2150269898 @default.
• W1987869069 cites W2163135881 @default.
• W1987869069 cites W2163591703 @default.
• W1987869069 cites W2169903102 @default.
• W1987869069 cites W2319767540 @default.
• W1987869069 doi "https://doi.org/10.1038/ajg.2009.281" @default.
• W1987869069 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2866652" @default.
• W1987869069 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19513025" @default.
• W1987869069 hasPublicationYear "2009" @default.
• W1987869069 type Work @default.
• W1987869069 sameAs 1987869069 @default.
• W1987869069 citedByCount "47" @default.
• W1987869069 countsByYear W19878690692012 @default.
• W1987869069 countsByYear W19878690692013 @default.
• W1987869069 countsByYear W19878690692014 @default.
• W1987869069 countsByYear W19878690692015 @default.
• W1987869069 countsByYear W19878690692016 @default.
• W1987869069 countsByYear W19878690692017 @default.
• W1987869069 countsByYear W19878690692018 @default.
• W1987869069 countsByYear W19878690692019 @default.
• W1987869069 countsByYear W19878690692020 @default.
• W1987869069 countsByYear W19878690692021 @default.
• W1987869069 countsByYear W19878690692022 @default.
• W1987869069 countsByYear W19878690692023 @default.
• W1987869069 crossrefType "journal-article" @default.
• W1987869069 hasAuthorship W1987869069A5001060980 @default.
• W1987869069 hasAuthorship W1987869069A5004733324 @default.
• W1987869069 hasAuthorship W1987869069A5011491566 @default.
• W1987869069 hasAuthorship W1987869069A5018121170 @default.
• W1987869069 hasAuthorship W1987869069A5037989560 @default.
• W1987869069 hasAuthorship W1987869069A5038373228 @default.

• next