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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987870527> ?p ?o ?g. }

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• W1987870527 abstract "The currently approved treatment for hepatitis C virus infections is a combination of Ribavirin and pegylated Interferon. It leads to a sustained virologic response in approximately only half of the patients treated. For this reason there is an urgent need of new therapeutic agents. 2′-C-Methylcytidine is the first nucleoside inhibitor of the HCV NS5B polymerase that was efficacious in reducing the viral load in patients infected with HCV. The application of a monophosphate prodrug approach based on unprecedented cyclic phosphoramidates is reported. Our SAR studies led to compounds that are efficiently converted to the active triphosphate in human hepatocytes." @default.
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• W1987870527 date "2009-09-01" @default.
• W1987870527 modified "2023-10-10" @default.
• W1987870527 title "Cyclic phosphoramidates as prodrugs of 2′-C-methylcytidine" @default.
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• W1987870527 doi "https://doi.org/10.1016/j.ejmech.2009.04.043" @default.
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