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- W1987872260 abstract "Immune serum obtained from mice with a chronic infection of Trypanosoma cruzi was fractionated on Sephadex G-200 or on protein ASepharose 4B. Mice were infected with a standard infective dose of T. cruzi 24 hr after injection with either IgM, IgG, IgG1, or IgG2 + IgG3 fractions. Mice were also pretreated with immune serum depleted by affinity chromatography of either IgG2a, IgG2b, or both subclasses before infection with T. cruzi. Control mice were pretreated with normal mouse serum or immune serum depleted of IgG. The parasitemia and survival of the animals were determined and used as parameters of protection. The results of these experiments demonstrated that the protective antibodies were mostly IgG2 and seem to be preferentially located in IgG2b subclass. IgM and IgG1 fractions were very little, if any, protection." @default.
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- W1987872260 date "1981-08-01" @default.
- W1987872260 modified "2023-09-30" @default.
- W1987872260 title "Trypanosoma cruzi: Role of different antibody classes in protection against infection in the mouse" @default.
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- W1987872260 doi "https://doi.org/10.1016/0014-4894(81)90069-2" @default.
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