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• W1987876633 abstract "Malaria is a disease that has a major impact in many developing nations, especially on the African continent. There is a need to develop new therapeutics and prophylactic treatments against it. A trisubstituted pyrrole was recently found to inhibit infection of mammalian hepatocytes by Plasmodium sporozoites, but the target of this agent is not known. In this study trisubstituted pyrrole derivatives with different substituents on a piperidinyl nitrogen were prepared. We determined if modifications of the piperidinyl nitrogen would accommodate a drug–biotin linking strategy for affinity purification of the trisubstituted pyrrole’s target protein(s)." @default.
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• W1987876633 date "2013-03-01" @default.
• W1987876633 modified "2023-10-16" @default.
• W1987876633 title "Chemical probes of a trisubstituted pyrrole to identify its protein target(s) in Plasmodium sporozoites" @default.
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• W1987876633 doi "https://doi.org/10.1016/j.bmcl.2013.01.010" @default.
• W1987876633 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5509439" @default.
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