Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987883931> ?p ?o ?g. }
- W1987883931 endingPage "47" @default.
- W1987883931 startingPage "41" @default.
- W1987883931 abstract "It has been proposed that Alzheimer disease (AD) is associated with a “disconnection syndrome” due to the gradual loss of morphological and functional integrity of cortico-cortical pathways. This hypothesis derives from indirect neuropathological observations, but definitive evidence that AD primarily targets cortico-cortical networks is still lacking. By means of neuroanatomical anterograde tracing methods, we have investigated, in a murine transgenic model of AD, the impact of the amyloid burden on axonal terminals in different neural systems. Axonal tracings revealed, in accordance with the “disconnection syndrome” hypothesis, that cortico-cortical fibers are significantly disorganized. Terminal fields in local and distant cortical areas contained numerous swollen dystrophic neurites often grouped in grape-like clusters at the plaque periphery. In contrary to fibers of cortical origin, those originating from subcortical brain structures only showed limited signs of degeneration upon reaching their cortical targets. These observations suggest a selective disruption of cortico-cortical connections induced by AD brain pathology." @default.
- W1987883931 created "2016-06-24" @default.
- W1987883931 creator A5008677196 @default.
- W1987883931 creator A5010403794 @default.
- W1987883931 creator A5039383646 @default.
- W1987883931 creator A5063954532 @default.
- W1987883931 date "2004-06-01" @default.
- W1987883931 modified "2023-10-16" @default.
- W1987883931 title "Alzheimer pathology disorganizes cortico-cortical circuitry: direct evidence from a transgenic animal model" @default.
- W1987883931 cites W1607410253 @default.
- W1987883931 cites W1983594867 @default.
- W1987883931 cites W1988066340 @default.
- W1987883931 cites W1991179725 @default.
- W1987883931 cites W1991500873 @default.
- W1987883931 cites W1992117629 @default.
- W1987883931 cites W1993812357 @default.
- W1987883931 cites W1995344309 @default.
- W1987883931 cites W1997351337 @default.
- W1987883931 cites W1998880269 @default.
- W1987883931 cites W2002581515 @default.
- W1987883931 cites W2003873096 @default.
- W1987883931 cites W2012215271 @default.
- W1987883931 cites W2014460483 @default.
- W1987883931 cites W2021904740 @default.
- W1987883931 cites W2023248571 @default.
- W1987883931 cites W2031127808 @default.
- W1987883931 cites W2038098976 @default.
- W1987883931 cites W2041436943 @default.
- W1987883931 cites W2048532208 @default.
- W1987883931 cites W2049691406 @default.
- W1987883931 cites W2052850418 @default.
- W1987883931 cites W2065327124 @default.
- W1987883931 cites W2067763320 @default.
- W1987883931 cites W2070928354 @default.
- W1987883931 cites W2074725453 @default.
- W1987883931 cites W2076467891 @default.
- W1987883931 cites W2079192770 @default.
- W1987883931 cites W2080516466 @default.
- W1987883931 cites W2081791223 @default.
- W1987883931 cites W2083358395 @default.
- W1987883931 cites W2086355707 @default.
- W1987883931 cites W2105704879 @default.
- W1987883931 cites W2121428135 @default.
- W1987883931 cites W2122230892 @default.
- W1987883931 cites W2126793161 @default.
- W1987883931 cites W2146729934 @default.
- W1987883931 cites W2148568069 @default.
- W1987883931 cites W2160129410 @default.
- W1987883931 cites W2309661748 @default.
- W1987883931 cites W4300414726 @default.
- W1987883931 doi "https://doi.org/10.1016/j.nbd.2004.01.008" @default.
- W1987883931 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15207260" @default.
- W1987883931 hasPublicationYear "2004" @default.
- W1987883931 type Work @default.
- W1987883931 sameAs 1987883931 @default.
- W1987883931 citedByCount "60" @default.
- W1987883931 countsByYear W19878839312012 @default.
- W1987883931 countsByYear W19878839312013 @default.
- W1987883931 countsByYear W19878839312014 @default.
- W1987883931 countsByYear W19878839312015 @default.
- W1987883931 countsByYear W19878839312016 @default.
- W1987883931 countsByYear W19878839312019 @default.
- W1987883931 countsByYear W19878839312020 @default.
- W1987883931 countsByYear W19878839312021 @default.
- W1987883931 countsByYear W19878839312022 @default.
- W1987883931 countsByYear W19878839312023 @default.
- W1987883931 crossrefType "journal-article" @default.
- W1987883931 hasAuthorship W1987883931A5008677196 @default.
- W1987883931 hasAuthorship W1987883931A5010403794 @default.
- W1987883931 hasAuthorship W1987883931A5039383646 @default.
- W1987883931 hasAuthorship W1987883931A5063954532 @default.
- W1987883931 hasBestOaLocation W19878839312 @default.
- W1987883931 hasConcept C102230213 @default.
- W1987883931 hasConcept C104317684 @default.
- W1987883931 hasConcept C141035611 @default.
- W1987883931 hasConcept C142724271 @default.
- W1987883931 hasConcept C169760540 @default.
- W1987883931 hasConcept C17744445 @default.
- W1987883931 hasConcept C199539241 @default.
- W1987883931 hasConcept C2780371621 @default.
- W1987883931 hasConcept C2781041448 @default.
- W1987883931 hasConcept C2983650178 @default.
- W1987883931 hasConcept C55493867 @default.
- W1987883931 hasConcept C71924100 @default.
- W1987883931 hasConcept C86803240 @default.
- W1987883931 hasConceptScore W1987883931C102230213 @default.
- W1987883931 hasConceptScore W1987883931C104317684 @default.
- W1987883931 hasConceptScore W1987883931C141035611 @default.
- W1987883931 hasConceptScore W1987883931C142724271 @default.
- W1987883931 hasConceptScore W1987883931C169760540 @default.
- W1987883931 hasConceptScore W1987883931C17744445 @default.
- W1987883931 hasConceptScore W1987883931C199539241 @default.
- W1987883931 hasConceptScore W1987883931C2780371621 @default.
- W1987883931 hasConceptScore W1987883931C2781041448 @default.
- W1987883931 hasConceptScore W1987883931C2983650178 @default.
- W1987883931 hasConceptScore W1987883931C55493867 @default.
- W1987883931 hasConceptScore W1987883931C71924100 @default.
- W1987883931 hasConceptScore W1987883931C86803240 @default.