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- W1987886076 abstract "Schwann cells are the satellite cell of the peripheral nervous system, and they surround axons and motor nerve terminals. The review summarises evidence for the ion channels expressed by mammalian Schwann cells, their molecular nature and known or speculated functions. In addition, the recent evidence for gap junctions and cytoplasmic diffusion pathways within the myelin and the functional consequences of a lower-resistance myelin sheath are discussed. The main types of ion channel expressed by Schwann cells are K(+) channels, Cl(-) channels, Na(+) channels and Ca(2+) channels. Each is represented by a variety of sub-types. The molecular and biophysical characteristics of the cation channels expressed by Schwann cells are closely similar or identical to those of channels expressed in peripheral axons and elsewhere. In addition, Schwann cells express P(2)X ligand-gated ion channels. Possible in vivo roles for each ion channel type are discussed. Ion channel expression in culture could have a special function in driving or controlling cell proliferation and recent evidence indicates that some Ca(2+) channel and Kir channel expression in culture is dependent upon the presence of neurones and local electrical activity." @default.
- W1987886076 created "2016-06-24" @default.
- W1987886076 creator A5068102799 @default.
- W1987886076 date "2002-02-01" @default.
- W1987886076 modified "2023-10-15" @default.
- W1987886076 title "Electrophysiology of mammalian Schwann cells" @default.
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- W1987886076 doi "https://doi.org/10.1016/s0079-6107(02)00007-x" @default.
- W1987886076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12429109" @default.
- W1987886076 hasPublicationYear "2002" @default.
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