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- W1987888968 abstract "The insulin-like growth factor II (IGF2) is a polypeptide with structure homology to insulin which possesses mitogen activity, and imprinted with paternal allele. In order to elucidate the distribution of imprinting pattern and relationship between allele- and tissue-specific expression ofIGF2in growth and maturation of human tissues, we investigated allele-specific expression ofIGF2in a wide spectrum of normal maturated human tissues by a PCR-based assay and found monoallelic expression in all eight-type tissues tested except human adult liver. Moreover, when a RT-PCR based sensitive allele-specific primer extension for anApaI polymorphism within exon 9 ofIGF2was used, the analysis revealed the gene was normally imprinted in placenta; in contrast to the finding with placenta,IGF2transcripts were biallelically expressed in human adult liver. Our results have clearly demonstrated preferential paternal expression and tissue-specific imprinting pattern ofIGF2in all human tissues tested in this study. Collectively, sinceIGF2expression in developing fetal and adult liver is specified by distinct promoters, these extensive observations definitively indicate that transcriptional imprinting ofIGF2is more likely a promoter dependent manner." @default.
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- W1987888968 date "1997-04-01" @default.
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- W1987888968 title "Promoter-Dependent Tissue-Specific Expressive Nature of Imprinting Gene, Insulin-like Growth Factor II, in Human Tissues" @default.
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- W1987888968 doi "https://doi.org/10.1006/bbrc.1997.6431" @default.
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