FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987907150> ?p ?o ?g. }

• W1987907150 endingPage "716" @default.
• W1987907150 startingPage "703" @default.
• W1987907150 abstract "Mitochondrial DNA haplotypes are associated with various phenotypes, such as altered susceptibility to disease, environmental adaptations, and aging. Accumulating evidence suggests that mitochondrial DNA is essential for cell differentiation and the cell phenotype. However, the effects of different mitochondrial DNA haplotypes on differentiation and development remain to be determined. Using embryonic stem cell lines possessing the same Mus musculus chromosomes but harboring one of Mus musculus, Mus spretus, or Mus terricolor mitochondrial DNA haplotypes, we have determined the effects of different mitochondrial DNA haplotypes on chromosomal gene expression, differentiation, and mitochondrial metabolism. In undifferentiated and differentiating embryonic stem cells, we observed mitochondrial DNA haplotype-specific expression of genes involved in pluripotency, differentiation, mitochondrial energy metabolism, and DNA methylation. These mitochondrial DNA haplotypes also influenced the potential of embryonic stem cells to produce spontaneously beating cardiomyocytes. The differences in gene expression patterns and cardiomyocyte production were independent of ATP content, oxygen consumption, and respiratory capacity, which until now have been considered to be the primary roles of mitochondrial DNA. Differentiation of embryonic stem cells harboring the different mitochondrial DNA haplotypes in a 3D environment significantly increased chromosomal gene expression for all haplotypes during differentiation. However, haplotype-specific differences in gene expression patterns were maintained in this environment. Taken together, these results provide significant insight into the phenotypic consequences of mitochondrial DNA haplotypes and demonstrate their influence on differentiation and development. We propose that mitochondrial DNA haplotypes play a pivotal role in the process of differentiation and mediate the fate of the cell." @default.
• W1987907150 created "2016-06-24" @default.
• W1987907150 creator A5004335652 @default.
• W1987907150 creator A5004667100 @default.
• W1987907150 creator A5012662669 @default.
• W1987907150 creator A5012942304 @default.
• W1987907150 creator A5015115188 @default.
• W1987907150 creator A5021358192 @default.
• W1987907150 creator A5031653446 @default.
• W1987907150 creator A5046202195 @default.
• W1987907150 creator A5059343383 @default.
• W1987907150 creator A5062672772 @default.
• W1987907150 creator A5073148691 @default.
• W1987907150 creator A5076644192 @default.
• W1987907150 date "2013-03-24" @default.
• W1987907150 modified "2023-09-26" @default.
• W1987907150 title "Mitochondrial DNA Haplotypes Define Gene Expression Patterns in Pluripotent and Differentiating Embryonic Stem Cells" @default.
• W1987907150 cites W1511913178 @default.
• W1987907150 cites W1547667831 @default.
• W1987907150 cites W1580867012 @default.
• W1987907150 cites W1965653791 @default.
• W1987907150 cites W1966083128 @default.
• W1987907150 cites W1967590676 @default.
• W1987907150 cites W1968273049 @default.
• W1987907150 cites W1970785287 @default.
• W1987907150 cites W1972526628 @default.
• W1987907150 cites W1974024889 @default.
• W1987907150 cites W1977742361 @default.
• W1987907150 cites W1980026529 @default.
• W1987907150 cites W1980699340 @default.
• W1987907150 cites W1984981565 @default.
• W1987907150 cites W1989084095 @default.
• W1987907150 cites W1994539520 @default.
• W1987907150 cites W1994976745 @default.
• W1987907150 cites W1999438528 @default.
• W1987907150 cites W2001076497 @default.
• W1987907150 cites W2004796041 @default.
• W1987907150 cites W2005400213 @default.
• W1987907150 cites W2005758857 @default.
• W1987907150 cites W2011322953 @default.
• W1987907150 cites W2012206386 @default.
• W1987907150 cites W2015859699 @default.
• W1987907150 cites W2017035597 @default.
• W1987907150 cites W2025192477 @default.
• W1987907150 cites W2027635031 @default.
• W1987907150 cites W2030677003 @default.
• W1987907150 cites W2030790272 @default.
• W1987907150 cites W2034352044 @default.
• W1987907150 cites W2040188417 @default.
• W1987907150 cites W2045099525 @default.
• W1987907150 cites W2047195788 @default.
• W1987907150 cites W2051070943 @default.
• W1987907150 cites W2053153356 @default.
• W1987907150 cites W2057871160 @default.
• W1987907150 cites W2060890963 @default.
• W1987907150 cites W2061104433 @default.
• W1987907150 cites W2062118486 @default.
• W1987907150 cites W2066418617 @default.
• W1987907150 cites W2068780842 @default.
• W1987907150 cites W2072056861 @default.
• W1987907150 cites W2074498796 @default.
• W1987907150 cites W2075204347 @default.
• W1987907150 cites W2080262824 @default.
• W1987907150 cites W2083534507 @default.
• W1987907150 cites W2086005166 @default.
• W1987907150 cites W2093905196 @default.
• W1987907150 cites W2104088897 @default.
• W1987907150 cites W2105754268 @default.
• W1987907150 cites W2107883924 @default.
• W1987907150 cites W2109291482 @default.
• W1987907150 cites W2127367768 @default.
• W1987907150 cites W2129666171 @default.
• W1987907150 cites W2131434664 @default.
• W1987907150 cites W2133486230 @default.
• W1987907150 cites W2143594562 @default.
• W1987907150 cites W2143698448 @default.
• W1987907150 cites W2146173970 @default.
• W1987907150 cites W2155862946 @default.
• W1987907150 cites W2162288115 @default.
• W1987907150 cites W2165505691 @default.
• W1987907150 cites W80489294 @default.
• W1987907150 doi "https://doi.org/10.1002/stem.1313" @default.
• W1987907150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23307500" @default.
• W1987907150 hasPublicationYear "2013" @default.
• W1987907150 type Work @default.
• W1987907150 sameAs 1987907150 @default.
• W1987907150 citedByCount "65" @default.
• W1987907150 countsByYear W19879071502013 @default.
• W1987907150 countsByYear W19879071502014 @default.
• W1987907150 countsByYear W19879071502015 @default.
• W1987907150 countsByYear W19879071502016 @default.
• W1987907150 countsByYear W19879071502017 @default.
• W1987907150 countsByYear W19879071502018 @default.
• W1987907150 countsByYear W19879071502019 @default.
• W1987907150 countsByYear W19879071502020 @default.
• W1987907150 countsByYear W19879071502021 @default.
• W1987907150 countsByYear W19879071502022 @default.
• W1987907150 countsByYear W19879071502023 @default.

• next