Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987922097> ?p ?o ?g. }
- W1987922097 endingPage "465" @default.
- W1987922097 startingPage "459" @default.
- W1987922097 abstract "Activated glia, as a result of chronic inflammation, are associated with amyloid-beta peptide (Abeta) deposits in the brain of Alzheimer's disease (AD) patients. In vitro, glia are activated by Abeta inducing secretion of pro-inflammatory molecules. Recent studies have focused on soluble oligomers (or protofibrils) of Abeta as the toxic species in AD. In the present study, using rat astrocyte cultures, oligomeric Abeta induced initial high levels of IL-1beta decreasing over time and, in contrast, fibrillar Abeta increased IL-1beta levels over time. In addition, oligomeric Abeta, but not fibrillar Abeta, induced high levels of iNOS, NO, and TNF-alpha. Our results suggest that oligomers induced a profound, early inflammatory response, whereas fibrillar Abeta showed less increase of pro-inflammatory molecules, consistent with a more chronic form of inflammation." @default.
- W1987922097 created "2016-06-24" @default.
- W1987922097 creator A5004201417 @default.
- W1987922097 creator A5024523607 @default.
- W1987922097 creator A5046146318 @default.
- W1987922097 creator A5055589818 @default.
- W1987922097 creator A5060394127 @default.
- W1987922097 date "2005-04-01" @default.
- W1987922097 modified "2023-10-03" @default.
- W1987922097 title "Differential effects of oligomeric and fibrillar amyloid-β1–42 on astrocyte-mediated inflammation" @default.
- W1987922097 cites W1481263059 @default.
- W1987922097 cites W1584774790 @default.
- W1987922097 cites W1967940232 @default.
- W1987922097 cites W1969165181 @default.
- W1987922097 cites W1969844849 @default.
- W1987922097 cites W1972891705 @default.
- W1987922097 cites W1974194572 @default.
- W1987922097 cites W1976845082 @default.
- W1987922097 cites W1979185206 @default.
- W1987922097 cites W1987426556 @default.
- W1987922097 cites W1988254695 @default.
- W1987922097 cites W1988479770 @default.
- W1987922097 cites W1990636293 @default.
- W1987922097 cites W1990802251 @default.
- W1987922097 cites W1991763618 @default.
- W1987922097 cites W1992598058 @default.
- W1987922097 cites W1999206064 @default.
- W1987922097 cites W2001900724 @default.
- W1987922097 cites W2005466083 @default.
- W1987922097 cites W2007056331 @default.
- W1987922097 cites W2007158999 @default.
- W1987922097 cites W2008560923 @default.
- W1987922097 cites W2010088712 @default.
- W1987922097 cites W2015163544 @default.
- W1987922097 cites W2021009440 @default.
- W1987922097 cites W2023960956 @default.
- W1987922097 cites W2024304291 @default.
- W1987922097 cites W2026592886 @default.
- W1987922097 cites W2031925670 @default.
- W1987922097 cites W2035139640 @default.
- W1987922097 cites W2037690177 @default.
- W1987922097 cites W2038611817 @default.
- W1987922097 cites W2045028538 @default.
- W1987922097 cites W2055676865 @default.
- W1987922097 cites W2063236931 @default.
- W1987922097 cites W2071695496 @default.
- W1987922097 cites W2073516240 @default.
- W1987922097 cites W2077531002 @default.
- W1987922097 cites W2090465196 @default.
- W1987922097 cites W2091551200 @default.
- W1987922097 cites W2092735546 @default.
- W1987922097 cites W2093202085 @default.
- W1987922097 cites W2095329043 @default.
- W1987922097 cites W2096410114 @default.
- W1987922097 cites W2107406217 @default.
- W1987922097 cites W2116784956 @default.
- W1987922097 cites W2133631618 @default.
- W1987922097 cites W2142186280 @default.
- W1987922097 cites W2145904082 @default.
- W1987922097 cites W2150999725 @default.
- W1987922097 cites W2152362568 @default.
- W1987922097 cites W2155404741 @default.
- W1987922097 cites W2160072324 @default.
- W1987922097 cites W2164956116 @default.
- W1987922097 cites W2165021720 @default.
- W1987922097 cites W2168025729 @default.
- W1987922097 cites W2171311951 @default.
- W1987922097 cites W231832547 @default.
- W1987922097 cites W2331038954 @default.
- W1987922097 cites W2886692603 @default.
- W1987922097 cites W4296154147 @default.
- W1987922097 cites W4328001100 @default.
- W1987922097 doi "https://doi.org/10.1016/j.nbd.2004.12.013" @default.
- W1987922097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15755672" @default.
- W1987922097 hasPublicationYear "2005" @default.
- W1987922097 type Work @default.
- W1987922097 sameAs 1987922097 @default.
- W1987922097 citedByCount "202" @default.
- W1987922097 countsByYear W19879220972012 @default.
- W1987922097 countsByYear W19879220972013 @default.
- W1987922097 countsByYear W19879220972014 @default.
- W1987922097 countsByYear W19879220972015 @default.
- W1987922097 countsByYear W19879220972016 @default.
- W1987922097 countsByYear W19879220972017 @default.
- W1987922097 countsByYear W19879220972018 @default.
- W1987922097 countsByYear W19879220972019 @default.
- W1987922097 countsByYear W19879220972020 @default.
- W1987922097 countsByYear W19879220972021 @default.
- W1987922097 countsByYear W19879220972022 @default.
- W1987922097 countsByYear W19879220972023 @default.
- W1987922097 crossrefType "journal-article" @default.
- W1987922097 hasAuthorship W1987922097A5004201417 @default.
- W1987922097 hasAuthorship W1987922097A5024523607 @default.
- W1987922097 hasAuthorship W1987922097A5046146318 @default.
- W1987922097 hasAuthorship W1987922097A5055589818 @default.
- W1987922097 hasAuthorship W1987922097A5060394127 @default.
- W1987922097 hasConcept C142724271 @default.
- W1987922097 hasConcept C169760540 @default.