FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987937449> ?p ?o ?g. }

• W1987937449 endingPage "523" @default.
• W1987937449 startingPage "515" @default.
• W1987937449 abstract "With the failure of so many pre-clinical stroke studies to translate into the clinic, there is a need to find new therapeutics to minimize the extent of cellular damage and aid in functional recovery. Domain V (DV), the c-terminal protein fragment of the vascular basement membrane component, perlecan, was recently shown to afford significant protection in multiple transient middle cerebral artery occlusion stroke models. We sought here to determine whether DV might have similar therapeutic properties in a focal photothrombosis stroke model in both young and aged mice. Young (3-month old) and aged (24-month old) mice underwent photothrombotic stroke to the motor cortex and were then treated with DV or phosphate buffered saline vehicle at different initial time points up to 7 days. Stroke volume was analyzed histologically using cresyl violet and functional recovery assessed behaviorally on both the grid-walking and cylinder tasks. In young mice, DV administration resulted in a significant decrease in infarct volume when treatment started 3 or 6 h post-stroke. In aged mice, DV administration was only protective when started 3 h post-stroke. In addition to a decrease in the area of infarction, DV treatment was effective in significantly decreasing the number of foot-faults on the grid-walking task and improving use of the stroke-affected limb in the cylinder task in both young and aged. Previously, we have shown that DV can alter the expression profile of various astroglial markers. Consistent with our previous finding, treatment groups that showed therapeutic potential in both young and aged mice also showed an elevation in glial fibrillary acidic protein (GFAP) expression in peri-infarct regions. We conclude that DV is neuroprotective and affords significant improvements in functional recovery in both young and aged mice after focal ischemia. These data also highlight a therapeutic time-window shift that is narrower in aged compared with young mice and is associated with an elevation in GFAP expression and heightened astrogliosis." @default.
• W1987937449 created "2016-06-24" @default.
• W1987937449 creator A5001289218 @default.
• W1987937449 creator A5007129205 @default.
• W1987937449 creator A5027769726 @default.
• W1987937449 date "2013-06-07" @default.
• W1987937449 modified "2023-09-26" @default.
• W1987937449 title "Perlecan Domain V Is Neuroprotective and Affords Functional Improvement in a Photothrombotic Stroke Model in Young and Aged Mice" @default.
• W1987937449 cites W1966800711 @default.
• W1987937449 cites W1974662613 @default.
• W1987937449 cites W1979664762 @default.
• W1987937449 cites W1994567278 @default.
• W1987937449 cites W1996243257 @default.
• W1987937449 cites W2009779748 @default.
• W1987937449 cites W2011783556 @default.
• W1987937449 cites W2016685143 @default.
• W1987937449 cites W2024927304 @default.
• W1987937449 cites W2027941907 @default.
• W1987937449 cites W2033142272 @default.
• W1987937449 cites W2037190190 @default.
• W1987937449 cites W2038316924 @default.
• W1987937449 cites W2038636807 @default.
• W1987937449 cites W2042949663 @default.
• W1987937449 cites W2057291185 @default.
• W1987937449 cites W2077708730 @default.
• W1987937449 cites W2083683919 @default.
• W1987937449 cites W2084498863 @default.
• W1987937449 cites W2093728612 @default.
• W1987937449 cites W2095234263 @default.
• W1987937449 cites W2096236127 @default.
• W1987937449 cites W2099631417 @default.
• W1987937449 cites W2107091249 @default.
• W1987937449 cites W2109295763 @default.
• W1987937449 cites W2109503237 @default.
• W1987937449 cites W2120063527 @default.
• W1987937449 cites W2126328573 @default.
• W1987937449 cites W2148632386 @default.
• W1987937449 cites W2792583460 @default.
• W1987937449 cites W4245385289 @default.
• W1987937449 cites W4254868516 @default.
• W1987937449 doi "https://doi.org/10.1007/s12975-013-0266-1" @default.
• W1987937449 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3937769" @default.
• W1987937449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24323378" @default.
• W1987937449 hasPublicationYear "2013" @default.
• W1987937449 type Work @default.
• W1987937449 sameAs 1987937449 @default.
• W1987937449 citedByCount "27" @default.
• W1987937449 countsByYear W19879374492014 @default.
• W1987937449 countsByYear W19879374492016 @default.
• W1987937449 countsByYear W19879374492017 @default.
• W1987937449 countsByYear W19879374492018 @default.
• W1987937449 countsByYear W19879374492019 @default.
• W1987937449 countsByYear W19879374492020 @default.
• W1987937449 countsByYear W19879374492021 @default.
• W1987937449 countsByYear W19879374492022 @default.
• W1987937449 countsByYear W19879374492023 @default.
• W1987937449 crossrefType "journal-article" @default.
• W1987937449 hasAuthorship W1987937449A5001289218 @default.
• W1987937449 hasAuthorship W1987937449A5007129205 @default.
• W1987937449 hasAuthorship W1987937449A5027769726 @default.
• W1987937449 hasBestOaLocation W19879374492 @default.
• W1987937449 hasConcept C118552586 @default.
• W1987937449 hasConcept C126322002 @default.
• W1987937449 hasConcept C127413603 @default.
• W1987937449 hasConcept C15744967 @default.
• W1987937449 hasConcept C164705383 @default.
• W1987937449 hasConcept C16568411 @default.
• W1987937449 hasConcept C169760540 @default.
• W1987937449 hasConcept C22731427 @default.
• W1987937449 hasConcept C25498285 @default.
• W1987937449 hasConcept C2777557582 @default.
• W1987937449 hasConcept C2778041096 @default.
• W1987937449 hasConcept C2779450755 @default.
• W1987937449 hasConcept C2779965356 @default.
• W1987937449 hasConcept C2780645631 @default.
• W1987937449 hasConcept C42219234 @default.
• W1987937449 hasConcept C529278444 @default.
• W1987937449 hasConcept C541997718 @default.
• W1987937449 hasConcept C71924100 @default.
• W1987937449 hasConcept C78519656 @default.
• W1987937449 hasConcept C99508421 @default.
• W1987937449 hasConceptScore W1987937449C118552586 @default.
• W1987937449 hasConceptScore W1987937449C126322002 @default.
• W1987937449 hasConceptScore W1987937449C127413603 @default.
• W1987937449 hasConceptScore W1987937449C15744967 @default.
• W1987937449 hasConceptScore W1987937449C164705383 @default.
• W1987937449 hasConceptScore W1987937449C16568411 @default.
• W1987937449 hasConceptScore W1987937449C169760540 @default.
• W1987937449 hasConceptScore W1987937449C22731427 @default.
• W1987937449 hasConceptScore W1987937449C25498285 @default.
• W1987937449 hasConceptScore W1987937449C2777557582 @default.
• W1987937449 hasConceptScore W1987937449C2778041096 @default.
• W1987937449 hasConceptScore W1987937449C2779450755 @default.
• W1987937449 hasConceptScore W1987937449C2779965356 @default.
• W1987937449 hasConceptScore W1987937449C2780645631 @default.
• W1987937449 hasConceptScore W1987937449C42219234 @default.
• W1987937449 hasConceptScore W1987937449C529278444 @default.
• W1987937449 hasConceptScore W1987937449C541997718 @default.

• next