Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987950063> ?p ?o ?g. }
- W1987950063 endingPage "22" @default.
- W1987950063 startingPage "1" @default.
- W1987950063 abstract "Phospholipids play multiple and essential roles in cells, as components of biological membranes. Although phospholipid bilayers provide the supporting matrix and surface for many enzymatic reactions, their inherent reactivity and possible catalytic role have not been highlighted. As other biomolecules, phospholipids are frequent targets of nonenzymatic modifications by reactive substances including oxidants and glycating agents which conduct to the formation of advanced lipoxidation end products (ALEs) and advanced glycation end products (AGEs). There are some theoretical studies about the mechanisms of reactions related to these processes on phosphatidylethanolamine surfaces, which hypothesize that cell membrane phospholipids surface environment could enhance some reactions through a catalyst effect. On the other hand, the phospholipid bilayers are susceptible to oxidative damage by oxidant agents as reactive oxygen species (ROS). Molecular dynamics simulations performed on phospholipid bilayers models, which include modified phospholipids by these reactions and subsequent reactions that conduct to formation of ALEs and AGEs, have revealed changes in the molecular interactions and biophysical properties of these bilayers as consequence of these reactions. Then, more studies are desirable which could correlate the biophysics of modified phospholipids with metabolism in processes such as aging and diseases such as diabetes, atherosclerosis, and Alzheimer’s disease." @default.
- W1987950063 created "2016-06-24" @default.
- W1987950063 creator A5000288854 @default.
- W1987950063 creator A5048601132 @default.
- W1987950063 creator A5069454040 @default.
- W1987950063 creator A5072968336 @default.
- W1987950063 date "2015-01-01" @default.
- W1987950063 modified "2023-10-16" @default.
- W1987950063 title "Nonenzymatic Reactions above Phospholipid Surfaces of Biological Membranes: Reactivity of Phospholipids and Their Oxidation Derivatives" @default.
- W1987950063 cites W111695384 @default.
- W1987950063 cites W1207588145 @default.
- W1987950063 cites W1489937832 @default.
- W1987950063 cites W1514825360 @default.
- W1987950063 cites W1568605582 @default.
- W1987950063 cites W1598235393 @default.
- W1987950063 cites W1604900522 @default.
- W1987950063 cites W1609735481 @default.
- W1987950063 cites W170490648 @default.
- W1987950063 cites W1762647466 @default.
- W1987950063 cites W1964513960 @default.
- W1987950063 cites W1964613257 @default.
- W1987950063 cites W1965163823 @default.
- W1987950063 cites W1965349771 @default.
- W1987950063 cites W1965357938 @default.
- W1987950063 cites W1965548018 @default.
- W1987950063 cites W1966234811 @default.
- W1987950063 cites W1966357354 @default.
- W1987950063 cites W1968509850 @default.
- W1987950063 cites W1969189325 @default.
- W1987950063 cites W1970254279 @default.
- W1987950063 cites W1972451253 @default.
- W1987950063 cites W1974124877 @default.
- W1987950063 cites W1975825141 @default.
- W1987950063 cites W1976087136 @default.
- W1987950063 cites W1977304935 @default.
- W1987950063 cites W1981039166 @default.
- W1987950063 cites W1981748085 @default.
- W1987950063 cites W1981854298 @default.
- W1987950063 cites W1983178305 @default.
- W1987950063 cites W1985300272 @default.
- W1987950063 cites W1985524011 @default.
- W1987950063 cites W1986336802 @default.
- W1987950063 cites W1987883528 @default.
- W1987950063 cites W1988696548 @default.
- W1987950063 cites W1991655565 @default.
- W1987950063 cites W1991753446 @default.
- W1987950063 cites W1992683316 @default.
- W1987950063 cites W1992789201 @default.
- W1987950063 cites W1993071111 @default.
- W1987950063 cites W1994784580 @default.
- W1987950063 cites W1996684418 @default.
- W1987950063 cites W1997241998 @default.
- W1987950063 cites W1998575668 @default.
- W1987950063 cites W1999040292 @default.
- W1987950063 cites W1999159353 @default.
- W1987950063 cites W1999400817 @default.
- W1987950063 cites W1999932901 @default.
- W1987950063 cites W2002163454 @default.
- W1987950063 cites W2002777925 @default.
- W1987950063 cites W2005200517 @default.
- W1987950063 cites W2007452808 @default.
- W1987950063 cites W2008830533 @default.
- W1987950063 cites W2009843396 @default.
- W1987950063 cites W2013408378 @default.
- W1987950063 cites W2014422210 @default.
- W1987950063 cites W2015601874 @default.
- W1987950063 cites W2017041783 @default.
- W1987950063 cites W2017214714 @default.
- W1987950063 cites W2017812730 @default.
- W1987950063 cites W2018551035 @default.
- W1987950063 cites W2020468377 @default.
- W1987950063 cites W2020846340 @default.
- W1987950063 cites W2021680808 @default.
- W1987950063 cites W2021882008 @default.
- W1987950063 cites W2023192003 @default.
- W1987950063 cites W2024367623 @default.
- W1987950063 cites W2025411680 @default.
- W1987950063 cites W2026730612 @default.
- W1987950063 cites W2026885029 @default.
- W1987950063 cites W2028505648 @default.
- W1987950063 cites W2032555072 @default.
- W1987950063 cites W2033605440 @default.
- W1987950063 cites W2034358178 @default.
- W1987950063 cites W2034751488 @default.
- W1987950063 cites W2035812493 @default.
- W1987950063 cites W2036735222 @default.
- W1987950063 cites W2038743266 @default.
- W1987950063 cites W2039417863 @default.
- W1987950063 cites W2040541235 @default.
- W1987950063 cites W2040710919 @default.
- W1987950063 cites W2041108980 @default.
- W1987950063 cites W2043250256 @default.
- W1987950063 cites W2043799214 @default.
- W1987950063 cites W2044252394 @default.
- W1987950063 cites W2046138985 @default.
- W1987950063 cites W2046377239 @default.
- W1987950063 cites W2047871652 @default.
- W1987950063 cites W2048699875 @default.