Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987987555> ?p ?o ?g. }
- W1987987555 endingPage "768" @default.
- W1987987555 startingPage "762" @default.
- W1987987555 abstract "Human papillomavirus type 16 (HPV16), a causative agent of cervical cancers, encodes the E6 and E7 oncogenes, whose simultaneous expression is pivotal for malignant transformation and maintenance of malignant phenotypes. In the hope of developing a gene-specific therapy for HPV-related cancer, we examined the effects of E6 short-interfering RNA (siRNA) on the expression of these oncogenes and on the cell growth of HPV16-related cervical cancer cells. Using SiHa cervical cancer cells, we demonstrated that E6 siRNA decreased the levels of mRNA encoding E6 as well as that encoding E7 protein and also induced nuclear accumulation of p53, the most important target of E6. E6 siRNA suppressed monolayer and anchorage-independent growth of SiHa cells, which was associated with p21(CIP1/WAF1) induction and hypophosphorylation of retinoblastoma protein. Further, SiHa cells treated with E6 siRNA formed tumors in NOD/SCID mice that were significantly smaller than in those treated with control siRNA. Our results show HPV E6 siRNA as a candidate for gene-specific therapy for HPV-related cervical cancer." @default.
- W1987987555 created "2016-06-24" @default.
- W1987987555 creator A5010957149 @default.
- W1987987555 creator A5013090266 @default.
- W1987987555 creator A5045169479 @default.
- W1987987555 creator A5055536684 @default.
- W1987987555 creator A5060234429 @default.
- W1987987555 creator A5060337998 @default.
- W1987987555 creator A5074835045 @default.
- W1987987555 creator A5088825172 @default.
- W1987987555 date "2003-11-01" @default.
- W1987987555 modified "2023-10-16" @default.
- W1987987555 title "In vitro and in vivo growth suppression of human papillomavirus 16-positive cervical cancer cells by e6 siRNA" @default.
- W1987987555 cites W1500130815 @default.
- W1987987555 cites W1512653355 @default.
- W1987987555 cites W1518586105 @default.
- W1987987555 cites W1540314522 @default.
- W1987987555 cites W1611419331 @default.
- W1987987555 cites W1856360008 @default.
- W1987987555 cites W1864196634 @default.
- W1987987555 cites W190015672 @default.
- W1987987555 cites W1939687015 @default.
- W1987987555 cites W1966962049 @default.
- W1987987555 cites W1967960141 @default.
- W1987987555 cites W1971195407 @default.
- W1987987555 cites W1977299280 @default.
- W1987987555 cites W1980912932 @default.
- W1987987555 cites W1995768712 @default.
- W1987987555 cites W2006100734 @default.
- W1987987555 cites W2012547585 @default.
- W1987987555 cites W2015519364 @default.
- W1987987555 cites W2018316589 @default.
- W1987987555 cites W2020850118 @default.
- W1987987555 cites W2020923434 @default.
- W1987987555 cites W2022306557 @default.
- W1987987555 cites W2029735450 @default.
- W1987987555 cites W2030295209 @default.
- W1987987555 cites W2034496567 @default.
- W1987987555 cites W2037593765 @default.
- W1987987555 cites W2038500217 @default.
- W1987987555 cites W2040115433 @default.
- W1987987555 cites W2070061120 @default.
- W1987987555 cites W2072543946 @default.
- W1987987555 cites W2089218510 @default.
- W1987987555 cites W2098100188 @default.
- W1987987555 cites W2105272116 @default.
- W1987987555 cites W2108720228 @default.
- W1987987555 cites W2112349562 @default.
- W1987987555 cites W2121046447 @default.
- W1987987555 cites W2122706841 @default.
- W1987987555 cites W2129167287 @default.
- W1987987555 cites W2136111158 @default.
- W1987987555 cites W2138688363 @default.
- W1987987555 cites W2143648037 @default.
- W1987987555 cites W2150525034 @default.
- W1987987555 cites W2167415438 @default.
- W1987987555 cites W2169168530 @default.
- W1987987555 cites W2313962090 @default.
- W1987987555 cites W2330719376 @default.
- W1987987555 doi "https://doi.org/10.1016/j.ymthe.2003.08.004" @default.
- W1987987555 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14599809" @default.
- W1987987555 hasPublicationYear "2003" @default.
- W1987987555 type Work @default.
- W1987987555 sameAs 1987987555 @default.
- W1987987555 citedByCount "161" @default.
- W1987987555 countsByYear W19879875552012 @default.
- W1987987555 countsByYear W19879875552013 @default.
- W1987987555 countsByYear W19879875552014 @default.
- W1987987555 countsByYear W19879875552015 @default.
- W1987987555 countsByYear W19879875552016 @default.
- W1987987555 countsByYear W19879875552017 @default.
- W1987987555 countsByYear W19879875552018 @default.
- W1987987555 countsByYear W19879875552019 @default.
- W1987987555 countsByYear W19879875552020 @default.
- W1987987555 countsByYear W19879875552021 @default.
- W1987987555 countsByYear W19879875552022 @default.
- W1987987555 countsByYear W19879875552023 @default.
- W1987987555 crossrefType "journal-article" @default.
- W1987987555 hasAuthorship W1987987555A5010957149 @default.
- W1987987555 hasAuthorship W1987987555A5013090266 @default.
- W1987987555 hasAuthorship W1987987555A5045169479 @default.
- W1987987555 hasAuthorship W1987987555A5055536684 @default.
- W1987987555 hasAuthorship W1987987555A5060234429 @default.
- W1987987555 hasAuthorship W1987987555A5060337998 @default.
- W1987987555 hasAuthorship W1987987555A5074835045 @default.
- W1987987555 hasAuthorship W1987987555A5088825172 @default.
- W1987987555 hasBestOaLocation W19879875551 @default.
- W1987987555 hasConcept C104317684 @default.
- W1987987555 hasConcept C111599444 @default.
- W1987987555 hasConcept C119056186 @default.
- W1987987555 hasConcept C121608353 @default.
- W1987987555 hasConcept C153911025 @default.
- W1987987555 hasConcept C159047783 @default.
- W1987987555 hasConcept C166703698 @default.
- W1987987555 hasConcept C202751555 @default.
- W1987987555 hasConcept C207001950 @default.
- W1987987555 hasConcept C22615655 @default.
- W1987987555 hasConcept C2776577112 @default.