FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987998725> ?p ?o ?g. }

• W1987998725 endingPage "2872" @default.
• W1987998725 startingPage "2865" @default.
• W1987998725 abstract "Systemic delivery of specific therapeutic proteins by a parenteral route of administration is a recognized practice in the management of several gene defects and acquired diseases. As an alternative to repetitive parenteral administration, gene therapy may provide a novel means for systemic delivery of therapeutic proteins while improving patient compliance and therapeutic efficacy. However, for gene therapy to be an efficacious and safe approach to the clinical management of such diseases, gene expression must be tightly regulated. These investigations demonstrate precise in vivo control of protein expression from cells that are engineered to secrete human growth hormone (hGH) in response to stimulation by rapamycin. The cells were implanted intramuscularly into nu/nu mice and stimulated by intravenous or oral administration of rapamycin. In vivo experiments demonstrate that the activity and pharmacokinetics of rapamycin determine the level of serum hGH that result from the engineered cells. In addition, responsiveness of the cells to rapamycin, number of cells implanted, hGH expression kinetics, and the pharmacokinetics of hGH itself, also influence the circulating levels of hGH after rapamycin stimulation. Controlled manipulation of several of these parameters, either independently or in combination, allows for precise regulation of circulating hGH concentration in vivo." @default.
• W1987998725 created "2016-06-24" @default.
• W1987998725 creator A5018977062 @default.
• W1987998725 creator A5021324450 @default.
• W1987998725 creator A5035320303 @default.
• W1987998725 creator A5046914504 @default.
• W1987998725 creator A5060597032 @default.
• W1987998725 date "1997-12-01" @default.
• W1987998725 modified "2023-10-08" @default.
• W1987998725 title "Pharmacologic control of a humanized gene therapy system implanted into nude mice." @default.
• W1987998725 cites W1603650405 @default.
• W1987998725 cites W1970586355 @default.
• W1987998725 cites W1971177037 @default.
• W1987998725 cites W1975045667 @default.
• W1987998725 cites W1987005832 @default.
• W1987998725 cites W1999964184 @default.
• W1987998725 cites W2007095985 @default.
• W1987998725 cites W2009510013 @default.
• W1987998725 cites W2017304478 @default.
• W1987998725 cites W2018500061 @default.
• W1987998725 cites W2022704908 @default.
• W1987998725 cites W2026340793 @default.
• W1987998725 cites W2030326532 @default.
• W1987998725 cites W2031924148 @default.
• W1987998725 cites W2034713066 @default.
• W1987998725 cites W2050621654 @default.
• W1987998725 cites W2066723998 @default.
• W1987998725 cites W2077316010 @default.
• W1987998725 cites W2083898038 @default.
• W1987998725 cites W2088947878 @default.
• W1987998725 cites W2093979198 @default.
• W1987998725 cites W2117830565 @default.
• W1987998725 cites W2121015447 @default.
• W1987998725 cites W2126493366 @default.
• W1987998725 cites W2148083135 @default.
• W1987998725 cites W2402894438 @default.
• W1987998725 cites W28981592 @default.
• W1987998725 doi "https://doi.org/10.1172/jci119835" @default.
• W1987998725 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/508493" @default.
• W1987998725 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9389753" @default.
• W1987998725 hasPublicationYear "1997" @default.
• W1987998725 type Work @default.
• W1987998725 sameAs 1987998725 @default.
• W1987998725 citedByCount "53" @default.
• W1987998725 countsByYear W19879987252012 @default.
• W1987998725 countsByYear W19879987252015 @default.
• W1987998725 countsByYear W19879987252016 @default.
• W1987998725 countsByYear W19879987252022 @default.
• W1987998725 crossrefType "journal-article" @default.
• W1987998725 hasAuthorship W1987998725A5018977062 @default.
• W1987998725 hasAuthorship W1987998725A5021324450 @default.
• W1987998725 hasAuthorship W1987998725A5035320303 @default.
• W1987998725 hasAuthorship W1987998725A5046914504 @default.
• W1987998725 hasAuthorship W1987998725A5060597032 @default.
• W1987998725 hasBestOaLocation W19879987251 @default.
• W1987998725 hasConcept C104317684 @default.
• W1987998725 hasConcept C111599444 @default.
• W1987998725 hasConcept C112705442 @default.
• W1987998725 hasConcept C126322002 @default.
• W1987998725 hasConcept C135983454 @default.
• W1987998725 hasConcept C150903083 @default.
• W1987998725 hasConcept C207001950 @default.
• W1987998725 hasConcept C24998067 @default.
• W1987998725 hasConcept C25938499 @default.
• W1987998725 hasConcept C2776093070 @default.
• W1987998725 hasConcept C2911091166 @default.
• W1987998725 hasConcept C55493867 @default.
• W1987998725 hasConcept C71924100 @default.
• W1987998725 hasConcept C86803240 @default.
• W1987998725 hasConcept C98274493 @default.
• W1987998725 hasConceptScore W1987998725C104317684 @default.
• W1987998725 hasConceptScore W1987998725C111599444 @default.
• W1987998725 hasConceptScore W1987998725C112705442 @default.
• W1987998725 hasConceptScore W1987998725C126322002 @default.
• W1987998725 hasConceptScore W1987998725C135983454 @default.
• W1987998725 hasConceptScore W1987998725C150903083 @default.
• W1987998725 hasConceptScore W1987998725C207001950 @default.
• W1987998725 hasConceptScore W1987998725C24998067 @default.
• W1987998725 hasConceptScore W1987998725C25938499 @default.
• W1987998725 hasConceptScore W1987998725C2776093070 @default.
• W1987998725 hasConceptScore W1987998725C2911091166 @default.
• W1987998725 hasConceptScore W1987998725C55493867 @default.
• W1987998725 hasConceptScore W1987998725C71924100 @default.
• W1987998725 hasConceptScore W1987998725C86803240 @default.
• W1987998725 hasConceptScore W1987998725C98274493 @default.
• W1987998725 hasIssue "11" @default.
• W1987998725 hasLocation W19879987251 @default.
• W1987998725 hasLocation W19879987252 @default.
• W1987998725 hasLocation W19879987253 @default.
• W1987998725 hasLocation W19879987254 @default.
• W1987998725 hasOpenAccess W1987998725 @default.
• W1987998725 hasPrimaryLocation W19879987251 @default.
• W1987998725 hasRelatedWork W1587611090 @default.
• W1987998725 hasRelatedWork W1602083480 @default.
• W1987998725 hasRelatedWork W1996617040 @default.
• W1987998725 hasRelatedWork W2054739272 @default.
• W1987998725 hasRelatedWork W2079987784 @default.
• W1987998725 hasRelatedWork W2144336433 @default.

• next