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• W1988000632 endingPage "366" @default.
• W1988000632 startingPage "359" @default.
• W1988000632 abstract "Amphiregulin (AR) is a growth regulatory glycoprotein with significant amino acid homology to members of the epidermal growth factor (EGF) family. Its effects are mediated via the EGF receptor tyrosine kinase or through specific nuclear targeting sequences. In this study, the localization of immunoreactive AR was examined in paraformaldehyde glutaraldehyde fixed, paraffin-embedded human placentae and decidua obtained at various stages from 11 weeks to term pregnancy using the avidin-biotin complex /peroxidase method. In addition, the effects of AR on trophoblast proliferation were evaluated from 3 HTdR uptake by first trimester human trophoblast cells. Results revealed immunolocalization ofAR to the nucleus as well as the cytoplasm of the syncytiotrophoblast cell layer of chorionic villi until approximately week 18 ofgestation after which no immunostaining was detected. Villous and extravillous cytotrophoblast cells as well as decidual tissue were negative for AR at all gestational ages examined. In the presence of exogenous AR, there was a dose-dependent increase in proliferation of the trophoblast at AR concentrations ranging from 1–100 ng/ml. These results suggest that AR may be an important paracrine or juxtacrine growth stimulatory molecule for cytotrophoblast cells in situ early in gestation." @default.
• W1988000632 created "2016-06-24" @default.
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• W1988000632 date "1995-06-01" @default.
• W1988000632 modified "2023-09-26" @default.
• W1988000632 title "Localization of amphiregulin in the human placenta and decidua throughout gestation: Role in trophoblast growth" @default.
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• W1988000632 doi "https://doi.org/10.1016/0143-4004(95)90093-4" @default.
• W1988000632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7567798" @default.
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