FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988001089> ?p ?o ?g. }

• W1988001089 endingPage "1311" @default.
• W1988001089 startingPage "1307" @default.
• W1988001089 abstract "Methicillin- and cephem-resistant Staphylococcus aureus (137 strains) for which the cefazolin MICs are at least 25 micrograms/ml could be classified into low-resistance (83% of strains) and high-resistance (the remaining 17%) groups by the MIC of flomoxef (6315-S), a 1-oxacephalosporin. The MICs were less than 6.3 micrograms/ml and more than 12.5 micrograms/ml in the low- and high-resistance groups, respectively. All strains produced penicillin-binding protein 2' (PBP 2'), which has been associated with methicillin resistance and which has very low affinity for beta-lactam antibiotics. Production of PBP 2' was regulated differently in low- and high-resistance strains. With penicillinase-producing strains of the low-resistance group, cefazolin, cefamandole, and cefmetazole induced PBP 2' production about 5-fold, while flomoxef induced production 2.4-fold or less. In contrast, penicillinase-negative variants of low-resistance strains produced PBP 2' constitutively in large amounts and induction did not occur. With high-resistance strains, flomoxef induced PBP 2' to an extent similar to that of cefazolin in both penicillinase-producing and -negative strains, except for one strain in which the induction did not occur. The amount of PBP 2' induced by beta-lactam antibiotics in penicillinase-producing strains of the low-resistance group correlated well with resistance to each antibiotic. Large amounts of PBP 2' in penicillinase-negative variants of the low-resistance group did not raise the MICs of beta-lactam compounds, although these strains were more resistant when challenged with flomoxef for 2 h. Different regulation of PBP 2' production was demonstrated in the high- and low-resistance groups, and factor(s) other than PBP 2' were suggested to be involved in the methicillin resistance of high-resistance strains." @default.
• W1988001089 created "2016-06-24" @default.
• W1988001089 creator A5003236531 @default.
• W1988001089 creator A5029169959 @default.
• W1988001089 creator A5045616690 @default.
• W1988001089 creator A5067397259 @default.
• W1988001089 date "1987-09-01" @default.
• W1988001089 modified "2023-10-06" @default.
• W1988001089 title "Production of low-affinity penicillin-binding protein by low- and high-resistance groups of methicillin-resistant Staphylococcus aureus" @default.
• W1988001089 cites W1496562993 @default.
• W1988001089 cites W1527707199 @default.
• W1988001089 cites W1600107546 @default.
• W1988001089 cites W1969443515 @default.
• W1988001089 cites W1970416250 @default.
• W1988001089 cites W1976172065 @default.
• W1988001089 cites W1977406574 @default.
• W1988001089 cites W1991263416 @default.
• W1988001089 cites W1991665650 @default.
• W1988001089 cites W2000120461 @default.
• W1988001089 cites W2009552501 @default.
• W1988001089 cites W2016074319 @default.
• W1988001089 cites W2016468759 @default.
• W1988001089 cites W2017694791 @default.
• W1988001089 cites W2029391294 @default.
• W1988001089 cites W2036989796 @default.
• W1988001089 cites W2041349455 @default.
• W1988001089 cites W2050211738 @default.
• W1988001089 cites W2050460020 @default.
• W1988001089 cites W2062854340 @default.
• W1988001089 cites W2088319417 @default.
• W1988001089 cites W2123689798 @default.
• W1988001089 doi "https://doi.org/10.1128/aac.31.9.1307" @default.
• W1988001089 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/174932" @default.
• W1988001089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3499861" @default.
• W1988001089 hasPublicationYear "1987" @default.
• W1988001089 type Work @default.
• W1988001089 sameAs 1988001089 @default.
• W1988001089 citedByCount "77" @default.
• W1988001089 countsByYear W19880010892012 @default.
• W1988001089 countsByYear W19880010892014 @default.
• W1988001089 countsByYear W19880010892015 @default.
• W1988001089 countsByYear W19880010892017 @default.
• W1988001089 countsByYear W19880010892020 @default.
• W1988001089 countsByYear W19880010892021 @default.
• W1988001089 countsByYear W19880010892022 @default.
• W1988001089 crossrefType "journal-article" @default.
• W1988001089 hasAuthorship W1988001089A5003236531 @default.
• W1988001089 hasAuthorship W1988001089A5029169959 @default.
• W1988001089 hasAuthorship W1988001089A5045616690 @default.
• W1988001089 hasAuthorship W1988001089A5067397259 @default.
• W1988001089 hasBestOaLocation W19880010892 @default.
• W1988001089 hasConcept C174802600 @default.
• W1988001089 hasConcept C2776237055 @default.
• W1988001089 hasConcept C2776368647 @default.
• W1988001089 hasConcept C2776653525 @default.
• W1988001089 hasConcept C2778353156 @default.
• W1988001089 hasConcept C2779074116 @default.
• W1988001089 hasConcept C2779489039 @default.
• W1988001089 hasConcept C2780463255 @default.
• W1988001089 hasConcept C501593827 @default.
• W1988001089 hasConcept C523546767 @default.
• W1988001089 hasConcept C54355233 @default.
• W1988001089 hasConcept C55493867 @default.
• W1988001089 hasConcept C64778159 @default.
• W1988001089 hasConcept C86803240 @default.
• W1988001089 hasConcept C89423630 @default.
• W1988001089 hasConceptScore W1988001089C174802600 @default.
• W1988001089 hasConceptScore W1988001089C2776237055 @default.
• W1988001089 hasConceptScore W1988001089C2776368647 @default.
• W1988001089 hasConceptScore W1988001089C2776653525 @default.
• W1988001089 hasConceptScore W1988001089C2778353156 @default.
• W1988001089 hasConceptScore W1988001089C2779074116 @default.
• W1988001089 hasConceptScore W1988001089C2779489039 @default.
• W1988001089 hasConceptScore W1988001089C2780463255 @default.
• W1988001089 hasConceptScore W1988001089C501593827 @default.
• W1988001089 hasConceptScore W1988001089C523546767 @default.
• W1988001089 hasConceptScore W1988001089C54355233 @default.
• W1988001089 hasConceptScore W1988001089C55493867 @default.
• W1988001089 hasConceptScore W1988001089C64778159 @default.
• W1988001089 hasConceptScore W1988001089C86803240 @default.
• W1988001089 hasConceptScore W1988001089C89423630 @default.
• W1988001089 hasIssue "9" @default.
• W1988001089 hasLocation W19880010891 @default.
• W1988001089 hasLocation W19880010892 @default.
• W1988001089 hasOpenAccess W1988001089 @default.
• W1988001089 hasPrimaryLocation W19880010891 @default.
• W1988001089 hasRelatedWork W1742301599 @default.
• W1988001089 hasRelatedWork W1981828377 @default.
• W1988001089 hasRelatedWork W1983165822 @default.
• W1988001089 hasRelatedWork W1988001089 @default.
• W1988001089 hasRelatedWork W2009717401 @default.
• W1988001089 hasRelatedWork W2013935350 @default.
• W1988001089 hasRelatedWork W2069153240 @default.
• W1988001089 hasRelatedWork W2342485030 @default.
• W1988001089 hasRelatedWork W2402852205 @default.
• W1988001089 hasRelatedWork W3206563132 @default.
• W1988001089 hasVolume "31" @default.
• W1988001089 isParatext "false" @default.

• next