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- W1988004507 abstract "A direct and scalable route to γ-keto-α,β-unsaturated esters, useful intermediates in medicinal chemistry and natural products synthesis, is reported. The key step involves the use of Grubbs' second-generation olefin metathesis catalyst for cross-metathesis of alkyl acrylates and 2° allylic alcohols. The metathesis step is followed by oxidation to give the desired products in high yield on scales of up to 25 g." @default.
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- W1988004507 date "2014-01-21" @default.
- W1988004507 modified "2023-10-09" @default.
- W1988004507 title "Grubbs Cross-Metathesis Pathway for a Scalable Synthesis of γ-Keto-α,β-unsaturated Esters" @default.
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- W1988004507 doi "https://doi.org/10.1021/jo4023606" @default.
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