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- W1988009411 abstract "Cognate interactions of naive T cells with antigen-presenting dendritic cells require physical cell–cell contacts leading to signal induction and T cell activation. Using a three-dimensional collagen matrix videomicroscopy model for ovalbumin peptide-specific activation of murine and oxidative mitogenesis of human T cells, we show that T cells maintain vigorous migration upon cognate interactions to DC (dendritic cell), continuously crawl across the DC surface, and rapidly detach (median within 6–12 min). These dynamic and short-lived encounters favor sequential contacts with the same or other DC and trigger calcium influx, upregulation of activation markers, T blast formation, and proliferation. We conclude that a tissue environment supports the accumulation of sequential signals, implicating a numeric or “digital” control mechanism for an ongoing primary immune response." @default.
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- W1988009411 date "2000-09-01" @default.
- W1988009411 modified "2023-10-17" @default.
- W1988009411 title "Antigen Presentation in Extracellular Matrix" @default.
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- W1988009411 doi "https://doi.org/10.1016/s1074-7613(00)00032-7" @default.
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