FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988009626> ?p ?o ?g. }

• W1988009626 endingPage "4179" @default.
• W1988009626 startingPage "4172" @default.
• W1988009626 abstract "Abstract Although iron chelation therapy with deferoxamine (DFO) results in improved life expectancy of patients with thalassemia, compliance with parenteral DFO treatment is unsatisfactory, underlining the need for alternative drugs and innovative ways of drug administration. We examined the chelating potential of pyridoxal isonicotinoyl hydrazone (PIH) analogs, alone or in combination with DFO, using hypertansfused rats with labeled hepatocellular iron stores and cultured iron-loaded rat heart cells. Our in vivo studies using 2 representative PIH analogs, 108-o and 109-o, have shown that PIH analogs given orally are 2.6 to 2.8 times more effective in mobilizing hepatocellular iron in rats, on a weight-per-weight basis, than parenteral DFO administered intraperitoneally. The combined effect of DFO and 108-o on hepatocellular iron excretion was additive, and response at a dose range of 25 to 200 mg/kg was linear. In vitro studies in heart cells showed that DFO was more effective in heart cell iron mobilization than all PIH analogs studied. Response to joint chelation with DFO and PIH analogs was similar to an increase in the equivalent molar dose of DFO alone, rather than the sum of the separate effects of the PIH analog and DFO. This finding was most likely the result of iron transfer from PIH analogs to DFO, a conclusion supported directly by iron-shuttle experiments using fluorescent DFO. These findings provide a rationale for the combined, simultaneous use of iron-chelating drugs and may have useful, practical implications for designing novel strategies of iron chelation therapy." @default.
• W1988009626 created "2016-06-24" @default.
• W1988009626 creator A5005090633 @default.
• W1988009626 creator A5012432039 @default.
• W1988009626 creator A5053661291 @default.
• W1988009626 creator A5056211046 @default.
• W1988009626 creator A5065072598 @default.
• W1988009626 creator A5075941488 @default.
• W1988009626 date "2003-05-15" @default.
• W1988009626 modified "2023-10-13" @default.
• W1988009626 title "Effects of combined chelation treatment with pyridoxal isonicotinoyl hydrazone analogs and deferoxamine in hypertransfused rats and in iron-loaded rat heart cells" @default.
• W1988009626 cites W100722149 @default.
• W1988009626 cites W1510484735 @default.
• W1988009626 cites W1534008913 @default.
• W1988009626 cites W1967102030 @default.
• W1988009626 cites W1978358795 @default.
• W1988009626 cites W1992125101 @default.
• W1988009626 cites W1995087031 @default.
• W1988009626 cites W2005969591 @default.
• W1988009626 cites W2009553907 @default.
• W1988009626 cites W2022102713 @default.
• W1988009626 cites W2025984741 @default.
• W1988009626 cites W2031476399 @default.
• W1988009626 cites W2034409947 @default.
• W1988009626 cites W2039715247 @default.
• W1988009626 cites W2047147969 @default.
• W1988009626 cites W2051690168 @default.
• W1988009626 cites W2052811636 @default.
• W1988009626 cites W2054689553 @default.
• W1988009626 cites W2064505263 @default.
• W1988009626 cites W2074897240 @default.
• W1988009626 cites W2077429231 @default.
• W1988009626 cites W2080711791 @default.
• W1988009626 cites W2084429638 @default.
• W1988009626 cites W2088232262 @default.
• W1988009626 cites W2089897480 @default.
• W1988009626 cites W2132319098 @default.
• W1988009626 cites W2146033714 @default.
• W1988009626 cites W2170247657 @default.
• W1988009626 cites W2317072972 @default.
• W1988009626 cites W2336706831 @default.
• W1988009626 cites W295614617 @default.
• W1988009626 cites W4229769638 @default.
• W1988009626 doi "https://doi.org/10.1182/blood-2002-08-2382" @default.
• W1988009626 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12511418" @default.
• W1988009626 hasPublicationYear "2003" @default.
• W1988009626 type Work @default.
• W1988009626 sameAs 1988009626 @default.
• W1988009626 citedByCount "37" @default.
• W1988009626 countsByYear W19880096262012 @default.
• W1988009626 countsByYear W19880096262013 @default.
• W1988009626 countsByYear W19880096262014 @default.
• W1988009626 countsByYear W19880096262015 @default.
• W1988009626 countsByYear W19880096262016 @default.
• W1988009626 countsByYear W19880096262018 @default.
• W1988009626 countsByYear W19880096262019 @default.
• W1988009626 countsByYear W19880096262020 @default.
• W1988009626 countsByYear W19880096262021 @default.
• W1988009626 crossrefType "journal-article" @default.
• W1988009626 hasAuthorship W1988009626A5005090633 @default.
• W1988009626 hasAuthorship W1988009626A5012432039 @default.
• W1988009626 hasAuthorship W1988009626A5053661291 @default.
• W1988009626 hasAuthorship W1988009626A5056211046 @default.
• W1988009626 hasAuthorship W1988009626A5065072598 @default.
• W1988009626 hasAuthorship W1988009626A5075941488 @default.
• W1988009626 hasBestOaLocation W19880096261 @default.
• W1988009626 hasConcept C150903083 @default.
• W1988009626 hasConcept C178790620 @default.
• W1988009626 hasConcept C179104552 @default.
• W1988009626 hasConcept C185592680 @default.
• W1988009626 hasConcept C197404232 @default.
• W1988009626 hasConcept C207001950 @default.
• W1988009626 hasConcept C2776517179 @default.
• W1988009626 hasConcept C2776672577 @default.
• W1988009626 hasConcept C2777218474 @default.
• W1988009626 hasConcept C2779365888 @default.
• W1988009626 hasConcept C29730261 @default.
• W1988009626 hasConcept C55493867 @default.
• W1988009626 hasConcept C71924100 @default.
• W1988009626 hasConcept C86803240 @default.
• W1988009626 hasConcept C98274493 @default.
• W1988009626 hasConceptScore W1988009626C150903083 @default.
• W1988009626 hasConceptScore W1988009626C178790620 @default.
• W1988009626 hasConceptScore W1988009626C179104552 @default.
• W1988009626 hasConceptScore W1988009626C185592680 @default.
• W1988009626 hasConceptScore W1988009626C197404232 @default.
• W1988009626 hasConceptScore W1988009626C207001950 @default.
• W1988009626 hasConceptScore W1988009626C2776517179 @default.
• W1988009626 hasConceptScore W1988009626C2776672577 @default.
• W1988009626 hasConceptScore W1988009626C2777218474 @default.
• W1988009626 hasConceptScore W1988009626C2779365888 @default.
• W1988009626 hasConceptScore W1988009626C29730261 @default.
• W1988009626 hasConceptScore W1988009626C55493867 @default.
• W1988009626 hasConceptScore W1988009626C71924100 @default.
• W1988009626 hasConceptScore W1988009626C86803240 @default.
• W1988009626 hasConceptScore W1988009626C98274493 @default.
• W1988009626 hasIssue "10" @default.
• W1988009626 hasLocation W19880096261 @default.

• next