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• W1988021144 abstract "<b>Background:</b><i>Helicobacter pylori</i> plays a decisive role in the pathogenesis of gastric marginal zone B cell lymphoma of mucosa associated lymphoid tissue (MALT), and eradication therapy has become a widely accepted initial treatment of stage I disease. <b>Objective:</b> To determine the long term outcome of patients undergoing exclusive <i>H pylori</i> eradication therapy. <b>Design:</b> A prospective series of patients with newly diagnosed marginal zone B cell lymphoma of MALT. <b>Setting:</b> Multicentre study in Germany and Austria. <b>Patients:</b> Ninety five patients; 90 of these (five lost to follow up) with a mean age of 54.3 (27–85) years were followed up for at least 12 months. <b>Intervention:</b> Complete staging work up revealing stage I disease and <i>H pylori</i> infection. Patients received triple therapy (OMC: omeprazole 20 mg twice daily, metronidazole 400 mg twice daily, and clarithromycin 250 mg twice daily; or OAC: omeprazole 20 mg twice daily, amoxycillin 1000 mg twice daily, and clarithromycin 500 twice daily) for one week. <b>Results:</b> Median follow up was 44.6 (12–89) months. <i>H pylori</i> was successfully eradicated in 88 patients (98%); in two patients eradication therapy failed. Long term outcome was characterised by complete regression of lymphoma in 56 patients (62%), minimal residual disease in 17 patients (18%), partial remission in 11 patients (12%), no change in four patients (4%), and progressive disease in two patients (2%). Four patients with complete remission relapsed after 6, 8, 8, and 15 months, one revealing reinfection by <i>H pylori</i>. Regression rate was higher in stage I1 disease compared with stage I2, as diagnosed by endoscopic ultrasound. <b>Conclusion:</b> The majority of patients with low grade gastric MALT lymphoma treated by exclusive <i>H pylori</i> eradication have a favourable long term outcome, offering a real chance of cure." @default.
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• W1988021144 date "2004-01-01" @default.
• W1988021144 modified "2023-10-04" @default.
• W1988021144 title "Long term outcome of patients with gastric marginal zone B cell lymphoma of mucosa associated lymphoid tissue (MALT) following exclusive Helicobacter pylori eradication therapy: experience from a large prospective series" @default.
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• W1988021144 doi "https://doi.org/10.1136/gut.53.1.34" @default.
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