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- W1988021435 abstract "The effects of recombinant human granulocytemacrophage colony-stimulating factor (rhGM-CSF) on neutrophil lactoferrin (LF) and transcobalamin (TC) 1 and 3 secretion were determined in vitro and during in vivo administration in humans. In whole blood, in vitro incubation with GM-CSF reproducibly produced a rise in plasma LF concentration (P<0.05) whereas in purified neutrophils the results were variable. Exposure of whole blood to GM-CSF also resulted in a significant rise in plasma TC 1 and 3 (190.60%, P<0.05). The response was dose dependent with maximal effect at GM-CSF concentrations of 10 ng/ml and above. rhGM-CSF was administered on seven occasions to six patients with malignant disease prior to chemotherapy. Plasma LF and unsaturated TC 1 and 3 levels rose significantly in each patient studied and the rise coincided with the initial neutropenia due to margination that occurs during infusions of rhGM-CSF. Patients receiving rhGM-CSF may therefore have hypofunctional neutrophils due to secondary granule depletion." @default.
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- W1988021435 date "1990-01-01" @default.
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- W1988021435 title "Secretion of neutrophil secondary granules occurs during granulocyte-macrophage colony stimulating factor induced margination" @default.
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- W1988021435 doi "https://doi.org/10.1111/j.1365-2141.1990.tb02532.x" @default.
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