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• W1988040315 abstract "Abstract The synthesis and evaluation of the biological activity of a series of pyridazin-3(2H)-one derivatives is reported. The compounds were tested in radioligand binding assays for affinity at A, and A 2A adenosine receptors in bovine brain cortical membranes, and bovine brain striatal membranes, respectively. None of the compounds shows any affinity towards A 2A receptor, while compounds in which the 6-chloro-pyridazin-3(2H)-one or 6-phenyl-pyridazin-3(2H)-one group is linked through a chain of two carbon atoms in the 6 position of the adenosine, show a good affinity towards A 1 adenosine receptor, particularly compound 8 in which a phenyl-pyridazinone group is present shows highest affinity with K i values 6.6 nM." @default.
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• W1988040315 date "1998-06-01" @default.
• W1988040315 modified "2023-09-27" @default.
• W1988040315 title "Adenosine receptors: synthesis, structure-activity relationships and biological activity of new 6-amino purine derivatives" @default.
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• W1988040315 doi "https://doi.org/10.1016/s0223-5234(98)80050-0" @default.
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