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- W1988045149 abstract "The mdx mouse is an animal model of muscular dystrophy. The goal of this project was to determine the effects of long-term prednisone treatment on ventilation and in vitro diaphragm muscle contractility in mdx mice. Three groups were studied: control (C57BL/10J, n = 9); mdx mice treated with a placebo (mdx-sham, n = 9); and mdx mice treated daily with prednisone (1mg/kg S.C.) (mdx-pred, n = 9) for 6 mo. After the treatment period, ventilation was measured in awake mice during room air breathing and in response to 7% CO2 using the barometric technique. There was no difference between groups during room air breathing for either tidal volume (Vt), respiratory rate (RR), or minute ventilation (Ve). In response to 7% CO2, Vt, RR, and Ve were all significantly lower (P < 0.05) in mdx-sham compared with control. In contrast, there was no difference in the above parameters between control and mdx-pred. Maximal isometric force (Po) was significantly higher in control (14.6 N/cm2) compared with both mdx-sham (5.8 N/cm2) and mdx-pred (6.4 N/cm2). These data suggest that long-term prednisone treatment improves ventilation in response to hypercapnia in mdx mice above that of untreated mdx mice but not equal to that of normal healthy controls. Long-term prednisone treatment however does not seem to improve diaphragm contractility. Supported by the American Lung Association and New York Affiliate." @default.
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- W1988045149 date "2001-05-01" @default.
- W1988045149 modified "2023-09-26" @default.
- W1988045149 title "IMPACT OF PREDNISONE ON VENTILATION AND DIAPHRAGM MUSCLE CONTRACTILITY IN MDX MICE" @default.
- W1988045149 doi "https://doi.org/10.1097/00005768-200105001-00326" @default.
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