Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988045190> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W1988045190 endingPage "1245" @default.
- W1988045190 startingPage "1240" @default.
- W1988045190 abstract "To improve clinical interpretation and use of in vitro clonogenic assay results, the authors reviewed their experience to date with chemosensitivity testing of over 1500 solid tumors. All clonogenic assays were performed using a double-layer-soft-agar system with continuous exposure of cells to one concentration of standard anticancer drugs. Significant growth was defined as > 30 colonies/control plate. Clinical responses were determined according to standard criteria. Data were analyzed using two different criteria of in vitro sensitivity (>50% and >75% inhibition of colony formation) and independently for each histologic type of tumor. Overall, 68% of specimens plated produced significant growth in vitro. Cloning ability varied from 57% to 82% depending on tumor histology. The assay was 57% reliable for predicting in vivo sensitivity, and 92% reliable for in vivo resistance. Predictive accuracy for sensitivity varied from 30% to 86%, depending on the tumor histology. Use of > 50% ICF (inhibition of colony formation) as criteria for differentiating sensitivity from resistance proved most reliable, although criteria should be individualized for each tumor type to maximize predictive accuracy. Cancer 53:1240-1245, 1984." @default.
- W1988045190 created "2016-06-24" @default.
- W1988045190 creator A5025311311 @default.
- W1988045190 creator A5028126765 @default.
- W1988045190 creator A5043465239 @default.
- W1988045190 creator A5061209536 @default.
- W1988045190 creator A5087416397 @default.
- W1988045190 date "1984-03-15" @default.
- W1988045190 modified "2023-09-24" @default.
- W1988045190 title "Chemosensitivity testing of human solid tumors. A review of 1582 assays with 258 clinical correlations" @default.
- W1988045190 cites W1981776296 @default.
- W1988045190 cites W1984613260 @default.
- W1988045190 cites W2000267361 @default.
- W1988045190 cites W2057916505 @default.
- W1988045190 cites W2062248445 @default.
- W1988045190 cites W2117523957 @default.
- W1988045190 cites W2320302422 @default.
- W1988045190 cites W2408903596 @default.
- W1988045190 cites W4253186968 @default.
- W1988045190 doi "https://doi.org/10.1002/1097-0142(19840315)53:6<1240::aid-cncr2820530604>3.0.co;2-y" @default.
- W1988045190 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6692313" @default.
- W1988045190 hasPublicationYear "1984" @default.
- W1988045190 type Work @default.
- W1988045190 sameAs 1988045190 @default.
- W1988045190 citedByCount "119" @default.
- W1988045190 countsByYear W19880451902012 @default.
- W1988045190 countsByYear W19880451902013 @default.
- W1988045190 countsByYear W19880451902014 @default.
- W1988045190 countsByYear W19880451902015 @default.
- W1988045190 countsByYear W19880451902016 @default.
- W1988045190 countsByYear W19880451902017 @default.
- W1988045190 countsByYear W19880451902021 @default.
- W1988045190 countsByYear W19880451902023 @default.
- W1988045190 crossrefType "journal-article" @default.
- W1988045190 hasAuthorship W1988045190A5025311311 @default.
- W1988045190 hasAuthorship W1988045190A5028126765 @default.
- W1988045190 hasAuthorship W1988045190A5043465239 @default.
- W1988045190 hasAuthorship W1988045190A5061209536 @default.
- W1988045190 hasAuthorship W1988045190A5087416397 @default.
- W1988045190 hasConcept C117262875 @default.
- W1988045190 hasConcept C121608353 @default.
- W1988045190 hasConcept C126322002 @default.
- W1988045190 hasConcept C142724271 @default.
- W1988045190 hasConcept C150903083 @default.
- W1988045190 hasConcept C202751555 @default.
- W1988045190 hasConcept C207001950 @default.
- W1988045190 hasConcept C2778076430 @default.
- W1988045190 hasConcept C2778660310 @default.
- W1988045190 hasConcept C502942594 @default.
- W1988045190 hasConcept C523546767 @default.
- W1988045190 hasConcept C54355233 @default.
- W1988045190 hasConcept C55493867 @default.
- W1988045190 hasConcept C57742111 @default.
- W1988045190 hasConcept C71924100 @default.
- W1988045190 hasConcept C86803240 @default.
- W1988045190 hasConceptScore W1988045190C117262875 @default.
- W1988045190 hasConceptScore W1988045190C121608353 @default.
- W1988045190 hasConceptScore W1988045190C126322002 @default.
- W1988045190 hasConceptScore W1988045190C142724271 @default.
- W1988045190 hasConceptScore W1988045190C150903083 @default.
- W1988045190 hasConceptScore W1988045190C202751555 @default.
- W1988045190 hasConceptScore W1988045190C207001950 @default.
- W1988045190 hasConceptScore W1988045190C2778076430 @default.
- W1988045190 hasConceptScore W1988045190C2778660310 @default.
- W1988045190 hasConceptScore W1988045190C502942594 @default.
- W1988045190 hasConceptScore W1988045190C523546767 @default.
- W1988045190 hasConceptScore W1988045190C54355233 @default.
- W1988045190 hasConceptScore W1988045190C55493867 @default.
- W1988045190 hasConceptScore W1988045190C57742111 @default.
- W1988045190 hasConceptScore W1988045190C71924100 @default.
- W1988045190 hasConceptScore W1988045190C86803240 @default.
- W1988045190 hasIssue "6" @default.
- W1988045190 hasLocation W19880451901 @default.
- W1988045190 hasLocation W19880451902 @default.
- W1988045190 hasOpenAccess W1988045190 @default.
- W1988045190 hasPrimaryLocation W19880451901 @default.
- W1988045190 hasRelatedWork W155402398 @default.
- W1988045190 hasRelatedWork W2013908504 @default.
- W1988045190 hasRelatedWork W2093518309 @default.
- W1988045190 hasRelatedWork W2100893712 @default.
- W1988045190 hasRelatedWork W2116564275 @default.
- W1988045190 hasRelatedWork W2333364158 @default.
- W1988045190 hasRelatedWork W2407812582 @default.
- W1988045190 hasRelatedWork W2409285845 @default.
- W1988045190 hasRelatedWork W2414997680 @default.
- W1988045190 hasRelatedWork W2475187018 @default.
- W1988045190 hasVolume "53" @default.
- W1988045190 isParatext "false" @default.
- W1988045190 isRetracted "false" @default.
- W1988045190 magId "1988045190" @default.
- W1988045190 workType "article" @default.