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- W1988049116 abstract "Allosteric modulation of a receptor may be proved experimentally by demonstrating an altered radioligand dissociation in the presence of the allosteric modulator. Two-point kinetic experiments provide a screening-type approach to determine the delay of radioligand dissociation caused by allosteric modulation. In this article, Evi Kostenis and Klaus Mohr describe a pitfall in the data analysis that may lead to a suboptimum determination of the allosteric potency in the case of monophasic dissociations, and suggest how this problem may be resolved." @default.
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- W1988049116 date "1996-08-01" @default.
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- W1988049116 title "Two-point kinetic experiments to quantify allosteric effects on radioligand dissociation" @default.
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- W1988049116 doi "https://doi.org/10.1016/0165-6147(96)10034-1" @default.
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