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- W1988049201 abstract "Phospholipase D3 (PLD3) is a non-classical, poorly characterized member of the PLD superfamily of signaling enzymes. PLD3 is a type II glycoprotein associated with the endoplasmic reticulum, is expressed in a wide range of tissues and cells, and undergoes dramatic upregulation in neurons and muscle cells during differentiation. Using an in vitro skeletal muscle differentiation system, we define the ER-tethering mechanism and report that increased PLD3 expression enhances myotube formation, whereas a putatively dominant-negative PLD3 mutant isoform reduces myotube formation. ER stress, which also enhances myotube formation, is shown here to increase PLD3 expression levels. PLD3 protein was observed to localize to a restricted set of subcellular membrane sites in myotubes that may derive from or constitute a subdomain of the endoplasmic reticulum. These findings suggest that PLD3 plays a role in myogenesis during myotube formation, potentially in the events surrounding ER reorganization." @default.
- W1988049201 created "2016-06-24" @default.
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- W1988049201 date "2012-03-12" @default.
- W1988049201 modified "2023-10-16" @default.
- W1988049201 title "A Role for Phospholipase D3 in Myotube Formation" @default.
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- W1988049201 doi "https://doi.org/10.1371/journal.pone.0033341" @default.
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