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- W1988052127 endingPage "74" @default.
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- W1988052127 abstract "Myocardial infarction (MI) is one of the leading causes of mortality worldwide and is associated with irreversible cardiomyocyte death and pathological remodeling of cardiac tissue. In the past 15 years, several animal models have been developed for pre-clinical testing to assess the potential of stem cells for functional tissue regeneration and the attenuation of left ventricular remodeling. The promising results obtained in terms of improved cardiac function, neo-angiogenesis and reduction in infarct size have motivated the initiation of clinical trials in humans. Despite the potential, the results of these studies have highlighted that the effective delivery and retention of viable cells within the heart remain significant challenges that have limited the therapeutic efficacy of cell-based therapies for treating the ischemic myocardium. In this review, we discuss key elements for designing clinically translatable cell-delivery approaches to promote myocardial regeneration. Key topics addressed include cell selection, with a focus on mesenchymal stem cells derived from the bone marrow (bMSCs) and adipose tissue (ASCs), including a discussion of their potential mechanisms of action. Natural and synthetic biomaterials that have been investigated as injectable cell delivery vehicles for cardiac applications are critically reviewed, including an analysis of the role of the biomaterials themselves in the therapeutic scheme." @default.
- W1988052127 created "2016-06-24" @default.
- W1988052127 creator A5024693115 @default.
- W1988052127 creator A5062100501 @default.
- W1988052127 creator A5068413403 @default.
- W1988052127 creator A5083290083 @default.
- W1988052127 creator A5090160348 @default.
- W1988052127 date "2014-04-01" @default.
- W1988052127 modified "2023-10-16" @default.
- W1988052127 title "Mesenchymal stem cell delivery strategies to promote cardiac regeneration following ischemic injury." @default.
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