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- W1988062439 abstract "ABSTRACT C14-progesterone was injected intravenously into 9 human subjects, 4 of whom had biliary fistulas. Following hydrolysis of steroid conjugates and continuous extraction with ether, the pooled urinary and pooled biliary extracts contained more than 50 per cent of the injected radioactivity. The extracts were separated into several fractions by counter-current distributions, followed by adsorption chromatography. Radioactive metabolites elutcd from alumina columns were characterized by isotope dilution with standard carriers in addition to chromatographic mobilities. Pregnanediol, allopregnanediol, pregnanolone and progesterone were identified in both urine and bile. Results indicate that hydroxylated metabolites of progesterone are eliminated mostly in the urine, while the corresponding ketonic compounds are excreted chiefly in the bile. INTRODUCTION THE principal pathway of the metabolism of progesterone is believed to be progesterone→pregnanedione→pregnanolone→pregnanediol,1 although small amount..." @default.
- W1988062439 created "2016-06-24" @default.
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- W1988062439 date "1960-12-01" @default.
- W1988062439 modified "2023-09-27" @default.
- W1988062439 title "BILIARY AND URINARY METABOLITES OF 4-C14-PROGESTERONE IN HUMAN SUBJECTS*" @default.
- W1988062439 doi "https://doi.org/10.1210/jcem-20-12-1568" @default.
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