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- W1988071798 abstract "Artemether-lumefantrine is a fixed-dose combination containing 20 mg artemether/120 mg lumefantrine per tablet, used for treating uncomplicated malaria in patients weighing ≥5 kg. It is the first artemisinin-based combination registered in some European countries and in the USA. It is marketed in Europe as Riamet(®) (Novartis, Basel, Switzerland) and in malaria-endemic countries as Coartem(®) (Novartis). Safety concerns prevent early pregnancy usage, while limited postmarketing surveillance has delayed safety assessment and policy development. Large clinical studies, postmarketing surveillance and pharmacovigillance ongoing in some countries may soon bridge safety issues. Fatty diet requirements for optimal absorption, pregnancy-induced changes in pharmacokinetics, pregnancy-related anorexia and food taboos, and emerging reduced parasite sensitivity to artemisinin, challenges optimal artemether-lumefantrine dosing and efficacy during pregnancy. This evaluation addresses drug usage, safety concerns following early exposure, implications for changed pharmacokinetics and reduced parasite susceptibility. Clinical-use updates and strategies to address some knowledge gaps including key operational research are discussed." @default.
- W1988071798 created "2016-06-24" @default.
- W1988071798 creator A5003302916 @default.
- W1988071798 creator A5014605112 @default.
- W1988071798 date "2013-02-01" @default.
- W1988071798 modified "2023-09-25" @default.
- W1988071798 title "Use of artemether–lumefantrine to treat malaria during pregnancy: what do we know and need to know?" @default.
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- W1988071798 doi "https://doi.org/10.1586/eri.12.169" @default.
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