FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988073619> ?p ?o ?g. }

• W1988073619 endingPage "e92515" @default.
• W1988073619 startingPage "e92515" @default.
• W1988073619 abstract "We previously reported that F4/80(+) Kupffer cells are subclassified into CD68(+) Kupffer cells with phagocytic and ROS producing capacity, and CD11b(+) Kupffer cells with cytokine-producing capacity. Carbon tetrachloride (CCl4)-induced hepatic injury is a well-known chemical-induced hepatocyte injury. In the present study, we investigated the immunological role of Kupffer cells/macrophages in CCl4-induced hepatitis in mice. The immunohistochemical analysis of the liver and the flow cytometry of the liver mononuclear cells showed that clodronate liposome (c-lipo) treatment greatly decreased the spindle-shaped F4/80(+) or CD68(+) cells, while the oval-shaped F4/80+ CD11b(+) cells increased. Notably, severe hepatic injury induced by CCl4 was further aggravated by c-lipo-pretreatment. The population of CD11b(+) Kupffer cells/macrophages dramatically increased 24 hour (h) after CCl4 administration, especially in c-lipo-pretreated mice. The CD11b(+) Kupffer cells expressed intracellular TNF and surface Fas-ligand (FasL). Furthermore, anti-TNF Ab pretreatment (which decreased the FasL expression of CD11b(+) Kupffer cells), anti-FasL Ab pretreatment or gld/gld mice attenuated the liver injury induced by CCl4. CD1d-/- mouse and cell depletion experiments showed that NKT cells and NK cells were not involved in the hepatic injury. The adoptive transfer and cytotoxic assay against primary cultured hepatocytes confirmed the role of CD11b(+) Kupffer cells in CCl4-induced hepatitis. Interestingly, the serum MCP-1 level rapidly increased and peaked at six h after c-lipo pretreatment, suggesting that the MCP-1 produced by c-lipo-phagocytized CD68(+) Kupffer cells may recruit CD11b(+) macrophages from the periphery and bone marrow. The CD11b(+) Kupffer cells producing TNF and FasL thus play a pivotal role in CCl4-induced acute hepatic injury." @default.
• W1988073619 created "2016-06-24" @default.
• W1988073619 creator A5011154182 @default.
• W1988073619 creator A5024110574 @default.
• W1988073619 creator A5030001987 @default.
• W1988073619 creator A5049580236 @default.
• W1988073619 creator A5052768130 @default.
• W1988073619 creator A5072750877 @default.
• W1988073619 creator A5076917742 @default.
• W1988073619 date "2014-03-25" @default.
• W1988073619 modified "2023-10-18" @default.
• W1988073619 title "Involvement of the TNF and FasL Produced by CD11b Kupffer Cells/Macrophages in CCl4-Induced Acute Hepatic Injury" @default.
• W1988073619 cites W1506174227 @default.
• W1988073619 cites W1509144440 @default.
• W1988073619 cites W1938170556 @default.
• W1988073619 cites W1965938315 @default.
• W1988073619 cites W1977168314 @default.
• W1988073619 cites W1977577140 @default.
• W1988073619 cites W1986141594 @default.
• W1988073619 cites W1987344938 @default.
• W1988073619 cites W1989018151 @default.
• W1988073619 cites W2006286083 @default.
• W1988073619 cites W2008998248 @default.
• W1988073619 cites W2018286119 @default.
• W1988073619 cites W2020411116 @default.
• W1988073619 cites W2044131495 @default.
• W1988073619 cites W2048799837 @default.
• W1988073619 cites W2058975659 @default.
• W1988073619 cites W2061772185 @default.
• W1988073619 cites W2065871536 @default.
• W1988073619 cites W2071179730 @default.
• W1988073619 cites W2071276803 @default.
• W1988073619 cites W2072584730 @default.
• W1988073619 cites W2075950996 @default.
• W1988073619 cites W2103289907 @default.
• W1988073619 cites W2111525805 @default.
• W1988073619 cites W2111550054 @default.
• W1988073619 cites W2111828785 @default.
• W1988073619 cites W2118531513 @default.
• W1988073619 cites W2130235708 @default.
• W1988073619 cites W2132508710 @default.
• W1988073619 cites W2133967889 @default.
• W1988073619 cites W2142361972 @default.
• W1988073619 cites W2143487048 @default.
• W1988073619 cites W2147509468 @default.
• W1988073619 cites W2320792628 @default.
• W1988073619 doi "https://doi.org/10.1371/journal.pone.0092515" @default.
• W1988073619 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3965417" @default.
• W1988073619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24667392" @default.
• W1988073619 hasPublicationYear "2014" @default.
• W1988073619 type Work @default.
• W1988073619 sameAs 1988073619 @default.
• W1988073619 citedByCount "62" @default.
• W1988073619 countsByYear W19880736192014 @default.
• W1988073619 countsByYear W19880736192015 @default.
• W1988073619 countsByYear W19880736192016 @default.
• W1988073619 countsByYear W19880736192017 @default.
• W1988073619 countsByYear W19880736192018 @default.
• W1988073619 countsByYear W19880736192019 @default.
• W1988073619 countsByYear W19880736192020 @default.
• W1988073619 countsByYear W19880736192021 @default.
• W1988073619 countsByYear W19880736192022 @default.
• W1988073619 countsByYear W19880736192023 @default.
• W1988073619 crossrefType "journal-article" @default.
• W1988073619 hasAuthorship W1988073619A5011154182 @default.
• W1988073619 hasAuthorship W1988073619A5024110574 @default.
• W1988073619 hasAuthorship W1988073619A5030001987 @default.
• W1988073619 hasAuthorship W1988073619A5049580236 @default.
• W1988073619 hasAuthorship W1988073619A5052768130 @default.
• W1988073619 hasAuthorship W1988073619A5072750877 @default.
• W1988073619 hasAuthorship W1988073619A5076917742 @default.
• W1988073619 hasBestOaLocation W19880736191 @default.
• W1988073619 hasConcept C102124568 @default.
• W1988073619 hasConcept C134018914 @default.
• W1988073619 hasConcept C153911025 @default.
• W1988073619 hasConcept C171779818 @default.
• W1988073619 hasConcept C178790620 @default.
• W1988073619 hasConcept C17991360 @default.
• W1988073619 hasConcept C185592680 @default.
• W1988073619 hasConcept C19702531 @default.
• W1988073619 hasConcept C202751555 @default.
• W1988073619 hasConcept C203014093 @default.
• W1988073619 hasConcept C204232928 @default.
• W1988073619 hasConcept C2776460901 @default.
• W1988073619 hasConcept C2776637226 @default.
• W1988073619 hasConcept C2777359374 @default.
• W1988073619 hasConcept C2778904781 @default.
• W1988073619 hasConcept C2779244956 @default.
• W1988073619 hasConcept C553184892 @default.
• W1988073619 hasConcept C55493867 @default.
• W1988073619 hasConcept C86803240 @default.
• W1988073619 hasConceptScore W1988073619C102124568 @default.
• W1988073619 hasConceptScore W1988073619C134018914 @default.
• W1988073619 hasConceptScore W1988073619C153911025 @default.
• W1988073619 hasConceptScore W1988073619C171779818 @default.
• W1988073619 hasConceptScore W1988073619C178790620 @default.
• W1988073619 hasConceptScore W1988073619C17991360 @default.
• W1988073619 hasConceptScore W1988073619C185592680 @default.

• next