Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988077413> ?p ?o ?g. }
- W1988077413 endingPage "92" @default.
- W1988077413 startingPage "86" @default.
- W1988077413 abstract "The human serum Sex Hormone-Binding Globulin (SHBG) plays an important role in breast cancer pathophysiology and risk definition, since it regulates the bioavailable fraction of circulating estradiol. We here summarize data reported over the years concerning the involvement of SHBG and SHBG polymorphisms in the definition of breast cancer risk. We also report what is known about the direct action of SHBG in breast cancer cells, illustrating its interaction with these cells and the subsequent initiation of a specific intracellular pathway leading to cross-talk with the estradiol-activated pathway and, finally, to the inhibition of several effects of estradiol in breast cancer cells. In conclusion, as a result of its unique property of regulating the estrogen free fraction and cross-talking with the estradiol pathways, by inhibiting estradiol-induced breast cancer cell growth and proliferation, SHBG is associated with a reduced risk of developing the neoplasm after estrogen exposure." @default.
- W1988077413 created "2016-06-24" @default.
- W1988077413 creator A5036532812 @default.
- W1988077413 creator A5051927874 @default.
- W1988077413 creator A5060312405 @default.
- W1988077413 creator A5062637381 @default.
- W1988077413 date "2010-03-01" @default.
- W1988077413 modified "2023-10-18" @default.
- W1988077413 title "Sex Hormone-Binding Globulin (SHBG), estradiol and breast cancer" @default.
- W1988077413 cites W1488927573 @default.
- W1988077413 cites W1497754723 @default.
- W1988077413 cites W1511930757 @default.
- W1988077413 cites W1518317724 @default.
- W1988077413 cites W1532668077 @default.
- W1988077413 cites W1600555406 @default.
- W1988077413 cites W1963676004 @default.
- W1988077413 cites W1966147885 @default.
- W1988077413 cites W1967607481 @default.
- W1988077413 cites W1968201285 @default.
- W1988077413 cites W1969043202 @default.
- W1988077413 cites W1969601708 @default.
- W1988077413 cites W1972743545 @default.
- W1988077413 cites W1972965832 @default.
- W1988077413 cites W1975926720 @default.
- W1988077413 cites W1976300959 @default.
- W1988077413 cites W1981813507 @default.
- W1988077413 cites W1988901915 @default.
- W1988077413 cites W1990065094 @default.
- W1988077413 cites W1991865867 @default.
- W1988077413 cites W1992405425 @default.
- W1988077413 cites W1995979471 @default.
- W1988077413 cites W1996171326 @default.
- W1988077413 cites W1999049330 @default.
- W1988077413 cites W2001888139 @default.
- W1988077413 cites W2010988152 @default.
- W1988077413 cites W2012285239 @default.
- W1988077413 cites W2012764774 @default.
- W1988077413 cites W2013128748 @default.
- W1988077413 cites W2016080351 @default.
- W1988077413 cites W2018115428 @default.
- W1988077413 cites W2020545781 @default.
- W1988077413 cites W2021632148 @default.
- W1988077413 cites W2021701128 @default.
- W1988077413 cites W2030269944 @default.
- W1988077413 cites W2031110943 @default.
- W1988077413 cites W2036263368 @default.
- W1988077413 cites W2036397716 @default.
- W1988077413 cites W2043164982 @default.
- W1988077413 cites W2043818636 @default.
- W1988077413 cites W2045389096 @default.
- W1988077413 cites W2047310786 @default.
- W1988077413 cites W2049654982 @default.
- W1988077413 cites W2050109158 @default.
- W1988077413 cites W2053510469 @default.
- W1988077413 cites W2055358324 @default.
- W1988077413 cites W2056811221 @default.
- W1988077413 cites W2062352409 @default.
- W1988077413 cites W2066281000 @default.
- W1988077413 cites W2067539975 @default.
- W1988077413 cites W2068593355 @default.
- W1988077413 cites W2069546754 @default.
- W1988077413 cites W2072787342 @default.
- W1988077413 cites W2074129415 @default.
- W1988077413 cites W2074290900 @default.
- W1988077413 cites W2080382275 @default.
- W1988077413 cites W2080457496 @default.
- W1988077413 cites W2082448317 @default.
- W1988077413 cites W2088398069 @default.
- W1988077413 cites W2089206274 @default.
- W1988077413 cites W2092723228 @default.
- W1988077413 cites W2093666377 @default.
- W1988077413 cites W2093869139 @default.
- W1988077413 cites W2094921517 @default.
- W1988077413 cites W2096946707 @default.
- W1988077413 cites W2113081221 @default.
- W1988077413 cites W2115379774 @default.
- W1988077413 cites W2119115875 @default.
- W1988077413 cites W2119237938 @default.
- W1988077413 cites W2121071871 @default.
- W1988077413 cites W2122174227 @default.
- W1988077413 cites W2122624008 @default.
- W1988077413 cites W2124361020 @default.
- W1988077413 cites W2126545533 @default.
- W1988077413 cites W2134222040 @default.
- W1988077413 cites W2139461145 @default.
- W1988077413 cites W2145635871 @default.
- W1988077413 cites W2161018040 @default.
- W1988077413 cites W2161762726 @default.
- W1988077413 cites W2163021406 @default.
- W1988077413 cites W2163864767 @default.
- W1988077413 cites W2170137499 @default.
- W1988077413 cites W2170803019 @default.
- W1988077413 cites W2171222096 @default.
- W1988077413 cites W2236669613 @default.
- W1988077413 cites W2324114402 @default.
- W1988077413 cites W27124366 @default.
- W1988077413 cites W4229610132 @default.
- W1988077413 cites W4241723439 @default.