Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988089431> ?p ?o ?g. }
- W1988089431 endingPage "419" @default.
- W1988089431 startingPage "408" @default.
- W1988089431 abstract "Metal based anticancer drugs have demonstrated their crucial role in preventing all types of cancers whereas their effectiveness is selective with respect to the cancer cells rather than the normal cells. Recently metal N-heterocyclic carbenes have established their selective performance for cancer cells excluding normal healthy cells based on which they are widely utilised for targeting cancer cells specifically which leads to cell death or cell growth inhibition. This is mainly due to their ionic character which helps them to localise in cancer cells with the help of enhanced expression of Organic Cation Transporters (OCT). Also their unique mechanism of action involving DNA binding, less recognizable by DNA repair machinery, mitochondria targeting gives them a new area for anticancer drug development. This review summarises the medicinal as well as pharmacological approach to the anticancer properties of metal NHC complexes." @default.
- W1988089431 created "2016-06-24" @default.
- W1988089431 creator A5015213148 @default.
- W1988089431 creator A5026432984 @default.
- W1988089431 creator A5040108669 @default.
- W1988089431 creator A5059384593 @default.
- W1988089431 date "2014-06-01" @default.
- W1988089431 modified "2023-10-16" @default.
- W1988089431 title "Recent developments of metal N-heterocyclic carbenes as anticancer agents" @default.
- W1988089431 cites W1847214777 @default.
- W1988089431 cites W1964185884 @default.
- W1988089431 cites W1967253297 @default.
- W1988089431 cites W1978521624 @default.
- W1988089431 cites W1980437676 @default.
- W1988089431 cites W1987059975 @default.
- W1988089431 cites W1998044143 @default.
- W1988089431 cites W2000510569 @default.
- W1988089431 cites W2002784664 @default.
- W1988089431 cites W2004674588 @default.
- W1988089431 cites W2004875516 @default.
- W1988089431 cites W2006143653 @default.
- W1988089431 cites W2009875413 @default.
- W1988089431 cites W2012076508 @default.
- W1988089431 cites W2017094452 @default.
- W1988089431 cites W2017227439 @default.
- W1988089431 cites W2017356116 @default.
- W1988089431 cites W2019107550 @default.
- W1988089431 cites W2020186674 @default.
- W1988089431 cites W2025380149 @default.
- W1988089431 cites W2026648170 @default.
- W1988089431 cites W2029434164 @default.
- W1988089431 cites W2031739323 @default.
- W1988089431 cites W2034023714 @default.
- W1988089431 cites W2034883681 @default.
- W1988089431 cites W2034920584 @default.
- W1988089431 cites W2040921537 @default.
- W1988089431 cites W2041167172 @default.
- W1988089431 cites W2044839376 @default.
- W1988089431 cites W2048458014 @default.
- W1988089431 cites W2057584058 @default.
- W1988089431 cites W2060900844 @default.
- W1988089431 cites W2062710883 @default.
- W1988089431 cites W2064247526 @default.
- W1988089431 cites W2068975708 @default.
- W1988089431 cites W2069358892 @default.
- W1988089431 cites W2070198602 @default.
- W1988089431 cites W2071039346 @default.
- W1988089431 cites W2075128676 @default.
- W1988089431 cites W2077625608 @default.
- W1988089431 cites W2078198776 @default.
- W1988089431 cites W2080977331 @default.
- W1988089431 cites W2081965503 @default.
- W1988089431 cites W2082047617 @default.
- W1988089431 cites W2087034705 @default.
- W1988089431 cites W2089096593 @default.
- W1988089431 cites W2093288014 @default.
- W1988089431 cites W2093345655 @default.
- W1988089431 cites W2093933962 @default.
- W1988089431 cites W2104057453 @default.
- W1988089431 cites W2127931645 @default.
- W1988089431 cites W2138313740 @default.
- W1988089431 cites W2140381813 @default.
- W1988089431 cites W2152048265 @default.
- W1988089431 cites W2154997242 @default.
- W1988089431 cites W2157897307 @default.
- W1988089431 cites W2160782716 @default.
- W1988089431 cites W2167245157 @default.
- W1988089431 cites W2172124462 @default.
- W1988089431 cites W2177162343 @default.
- W1988089431 cites W2319578742 @default.
- W1988089431 cites W2323180056 @default.
- W1988089431 cites W2323914507 @default.
- W1988089431 cites W2327814475 @default.
- W1988089431 cites W2337283428 @default.
- W1988089431 doi "https://doi.org/10.1016/j.ejmech.2014.05.036" @default.
- W1988089431 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24858545" @default.
- W1988089431 hasPublicationYear "2014" @default.
- W1988089431 type Work @default.
- W1988089431 sameAs 1988089431 @default.
- W1988089431 citedByCount "112" @default.
- W1988089431 countsByYear W19880894312014 @default.
- W1988089431 countsByYear W19880894312015 @default.
- W1988089431 countsByYear W19880894312016 @default.
- W1988089431 countsByYear W19880894312017 @default.
- W1988089431 countsByYear W19880894312018 @default.
- W1988089431 countsByYear W19880894312019 @default.
- W1988089431 countsByYear W19880894312020 @default.
- W1988089431 countsByYear W19880894312021 @default.
- W1988089431 countsByYear W19880894312022 @default.
- W1988089431 countsByYear W19880894312023 @default.
- W1988089431 crossrefType "journal-article" @default.
- W1988089431 hasAuthorship W1988089431A5015213148 @default.
- W1988089431 hasAuthorship W1988089431A5026432984 @default.
- W1988089431 hasAuthorship W1988089431A5040108669 @default.
- W1988089431 hasAuthorship W1988089431A5059384593 @default.
- W1988089431 hasConcept C121608353 @default.
- W1988089431 hasConcept C1491633281 @default.
- W1988089431 hasConcept C185592680 @default.